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Cell-cycle phase progression analysis identifies three unique phenotypes in soft tissue sarcoma.

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اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • Publisher Information:
      Springer Science and Business Media LLC https://doi.org/10.1186/s12885-024-13043-6 BMC Cancer 2024-10-17T14:43:59Z 2024-10-17 2024-03-28 2024-10-17T14:43:58Z
    • نبذة مختصرة :
      Acknowledgements: Not applicable.
      PURPOSE: Loddo et al. (Br J Cancer 100:959-70, 2009) established the prognostic significance of cell cycle markers and "Cell-Cycle Phenotypes" in breast carcinoma. This study aims to 1) identify prognostic cell-cycle markers in sarcoma, and 2) assess the prognostic potential of specific cell-cycle phenotypes in sarcoma. METHODS: Tissue samples from 128 soft tissue sarcomas were stained for four cell cycle-specific markers: Mcm2, Geminin, Plk1, and H3S10ph. Only primary soft tissue tumors (liposarcoma, leiomyosarcoma, synovial sarcoma, and undifferentiated pleomorphic sarcoma) were included in the analysis. Any tumor coming from a recurrent or metastatic lesion were excluded from the analysis. Three cell-cycle phenotypes (I, II, III) were derived from marker expression patterns. Prognostic significance was evaluated in a subset of primary soft tissue sarcomas using Cox regression for survival analysis. RESULTS: Compared to phenotype I, the phenotype III tumors had a decreased 5-year overall survival (HR 6.81 [2.36-19.61]; p = < 0.001), 5-year disease-free survival (HR 1.07 (1.02-1.18); p = 0.004), and 5-year metastasis-free survival (HR 4.34 [1.58-11.93]; p = 0.004). High expression of Plk1 was associated with decreased 5-year overall survival (HR: 4.04 CI [1.21-6.67; p = 0.02) and 5-year metastasis-free survival (HR: 2.91 CI [1.15-7.37]; p = 0.03). Geminin was also found to have a decreased 5-year overall survival (HR:2.84 CI [1.21-6.67]; p = 0.02). No statistical difference in prognostication were noted between phenotypes and the AJCC system. CONCLUSIONS: We identified three unique sarcoma cell cycle phenotypes that have prognostic significance. This performs similarly to the AJCC staging system.
    • الموضوع:
      Cell-cycle; Phenotypes; Prognosis; Sarcoma; Humans; Female; Phenotype; Middle Aged; Male; Adult; Cell Cycle Proteins; Cell Cycle; Aged; Biomarkers, Tumor; Aged, 80 and over; Young Adult; Polo-Like Kinase 1; Adolescent; Article
    • Availability:
      Open access content. Open access content
    • Note:
      application/zip
      application/pdf
      text/xml
      English
      English
    • Other Numbers:
      HS1 oai:www.repository.cam.ac.uk:1810/375088
      1488341168
    • Contributing Source:
      UNIV OF CAMBRIDGE
      From OAIster®, provided by the OCLC Cooperative.
    • الرقم المعرف:
      edsoai.on1488341168
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