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Neurobiological Correlates of Psychedelic Experiences and Psychedelic-Associated Adverse Effects

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  • معلومة اضافية
    • Publisher Information:
      Springer 2024-07-31 info:eu-repo/date/embargoEnd/2028-08-01
    • نبذة مختصرة :
      This chapter offers a comprehensive overview of our current understanding of the neural mechanisms underlying the effects of psychedelic drugs, with a primary focus on human neuroimaging studies. Whenever possible, we explore the neurobiological mechanisms that may underly acute and subacute adverse effects and describe hypotheses on how these results may inform on the pathophysiology of psychiatric illnesses. We delve into the general effects of psychedelics on EEG, fMRI, and PET measurements, drawing insights from experiments that have assessed their acute biological mechanisms. Additionally, we review the relatively limited literature exploring pre- to postdrug changes. Throughout this chapter, we explore the prevailing models of psychedelic drug actions, including the Cortico-Striato-Thalamo-Cortical (CSTC) feedback loop model, the entropic brain hypothesis, the REBUS principle (an extension of predictive brain theories), and the claustrum hypothesis. Finally, we delve into the neural correlates of distinct features of the psychedelic experience, encompassing visual effects, social and emotional impacts, and the phenomenon of ego dissolution. We offer speculations on how our current understanding of acute drug effects might relate to the rarely occurring long-term adverse effects. It is important to note that due to the scarcity of data, these speculations remain tentative.
    • الموضوع:
      Clinic for Psychiatry, Psychotherapy, and Psychosomatics; 142-005; 610 Medicine & health; Book Section; PeerReviewed; info:eu-repo/semantics/bookPart; info:eu-repo/semantics/publishedVersion
    • Availability:
      Open access content. Open access content
      info:eu-repo/semantics/embargoedAccess
      info:eu-repo/semantics/embargoedAccess
    • Note:
      application/pdf
      English
      English
    • Other Numbers:
      CHUZH oai:www.zora.uzh.ch:266462
      info:doi/10.5167/uzh-266462
      info:doi/10.1007/7854_2024_507
      info:pmid/39080245
      urn:issn:1866-3370
      1482156223
    • Contributing Source:
      HAUPTBIBLIOTHEK UNIV OF ZURICH
      From OAIster®, provided by the OCLC Cooperative.
    • الرقم المعرف:
      edsoai.on1482156223
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