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Pan-Echinocandin Resistant C. parapsilosis Harboring an F652S Fks1 Alteration in a Patient with Prolonged Echinocandin Therapy
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- المؤلفون: Siopi, M. Papadopoulos, A. Spiliopoulou, A. Paliogianni, F. Abou-Chakra, N. Arendrup, M.C. Damoulari, C. Tsioulos, G. Giannitsioti, E. Frantzeskaki, F. Tsangaris, I. Pournaras, S. Meletiadis, J.
- نوع التسجيلة:
Electronic Resource
- الدخول الالكتروني :
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3347916
- معلومة اضافية
- Publisher Information:
2022-01-01
- نبذة مختصرة :
The isolation of a pan-echinocandin-resistant Candida parapsilosis strain (anidulafungin, caspofungin, micafungin and rezafungin EUCAST MICs > 8 mg/L) from urine of a patient following prolonged exposure to echinocandins (38 days of micafungin followed by 16 days of anidulafungin) is described. The isolate harbored the novel alteration F652S in the hotspot 1 region of fks1. Isogenic C. parapsilosis bloodstream isolates collected up to 1.5 months earlier from the same patient were susceptible to echinocandins (anidulafungin, caspofungin and micafungin EUCAST MICs 1–2, 1 and 1 mg/L, respectively) and contained wild-type FKS1 sequences. This is the first report of pan-echinocandin resistance in C. parapsilosis associated with an aminoacid change in hotspot 1 region of fks1. © 2022 by the authors.
- الموضوع:
- Availability:
Open access content. Open access content
- Note:
English
- Other Numbers:
GRNKU oai:lib.uoa.gr:uoadl:3347916
uoadl:3347916
1478898839
- Contributing Source:
NATIONAL & KAPODISTRIAN UNIV OF ATHENS
From OAIster®, provided by the OCLC Cooperative.
- الرقم المعرف:
edsoai.on1478898839
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