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Quantification of bone microarchitecture using photon-counting CT at different radiation doses:A comparison with µCT

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اقرأ أكثر حفظ في قائمتي
  • المؤلفون: Kok, Joeri; Bevers, Melissa S.A.M.; van Rietbergen, Bert; Oei, Edwin H.G.; Booij, Ronald
  • المصدر:
    Kok , J , Bevers , M S A M , van Rietbergen , B , Oei , E H G & Booij , R 2024 , ' Quantification of bone microarchitecture using photon-counting CT at different radiation doses : A comparison with µCT ' , European Journal of Radiology , vol. 181 , 111717 .
  • نوع التسجيلة:
    Electronic Resource
  • الدخول الالكتروني :
    https://pure.eur.nl/en/publications/235c8770-98d5-4422-889f-b5a91a3bc617
  • معلومة اضافية
    • Publisher Information:
      2024-12
    • نبذة مختصرة :
      Purpose: Accurate measurements of trabecular bone microarchitecture are required for a proper assessment of bone fragility. Photon-counting detector CT (PCD-CT) has different technical properties than conventional CT, resulting in higher resolution and thereby potentially enabling in-vivo measurement of trabecular microarchitecture. The purpose of this study was to quantify trabecular bone microarchitectural parameters with PCD-CT at varying radiation doses and compare this to µCT as gold standard. Method: Both distal radii, distal tibiae, femoral heads, and two vertebrae were dissected from one human. All specimens were scanned ex-vivo on a PCD-CT system (slice increment 0.1 mm; pixel size 0.1042–0.127 mm) and a µCT system (isotropic voxel size 49–68.4 µm). The radiation doses of the PCD-CT scans were varied from 2.5 to 120 mGy based on the volume CT dose index (CTDIvol32). For the PCD-CT scans, contrast-to-noise ratio and trabecular sharpness were calculated and compared between radiation doses. µCT and PCD-CT scans were registered. The trabecular bone was then segmented from all PCD-CT and µCT scans and split into cubes with 6-mm edge length. For each cube, bone volume over total volume, trabecular thickness, trabecular number, and trabecular heterogeneity were calculated and compared between corresponding PCD-CT and µCT cubes. Results: With increasing dose, contrast-to-noise ratio and trabecular sharpness values increased for the PCD-CT images. Already at the lowest dose, high correlations between the trabecular microarchitectural parameters between µCT and PCD-CT were found (R2 = 0.55–0.95), which improved with increasing radiation dose (R2 = 0.76–0.96 at 20 mGy). Conclusions: PCD-CT can be used to quantify trabecular bone microarchitecture, with accuracy comparable to µCT and at clinically relevant radiation doses.
    • الموضوع:
      article
    • Availability:
      Open access content. Open access content
      info:eu-repo/semantics/openAccess
    • Note:
      application/pdf
      English
    • Other Numbers:
      QGQ oai:pure.eur.nl:publications/235c8770-98d5-4422-889f-b5a91a3bc617
      https://pure.eur.nl/en/publications/235c8770-98d5-4422-889f-b5a91a3bc617
      https://doi.org/10.1016/j.ejrad.2024.111717
      https://pure.eur.nl/ws/files/167538986/Quantification_of_bone_microarchitecture_using_photon-counting_CT_at_different_radiation_doses.pdf
      1456741325
    • Contributing Source:
      ERASMUS UNIVERSITEIT ROTTERDAM
      From OAIster®, provided by the OCLC Cooperative.
    • الرقم المعرف:
      edsoai.on1456741325
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