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Silk-elastin-like polymers for acute intraparenchymal treatment of the traumatically injured spinal cord: A first systematic experimental approach

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  • المؤلفون: González, Pau
  • نوع التسجيلة:
    Electronic Resource
  • الدخول الالكتروني :
    https://worldcat.org/search?q=on:ESUDE+http://uvadoc.uva.es/oai/request+DCG_ENTIRE_REPOSITORY+CNTCOLL
    https://www.mdpi.com/1999-4923/14/12/2713
    https://www.mdpi.com/1999-4923/14/12/2713
  • معلومة اضافية
    • Publisher Information:
      MDPI 2022
    • نبذة مختصرة :
      Producción Científica
      Despite the promising potential of hydrogel-based therapeutic approaches for spinal cord injury (SCI), the need for new biomaterials to design effective strategies for SCI treatment and the outstanding properties of silk-elastin-like polymers (SELP), the potential use of SELPs in SCI is currently unknown. In this context, we assessed the effects elicited by the in vivo acute intraparenchymal injection of an SELP named (EIS)2-RGD6 in a clinically relevant model of SCI. After optimization of the injection system, the distribution, structure, biodegradability, and cell infiltration capacity of (EIS)2-RGD6 were assessed. Finally, the effects exerted by the (EIS)2-RGD6 injection—in terms of motor function, myelin preservation, astroglial and microglia/macrophage reactivity, and fibrosis—were evaluated. We found that (EIS)2-RGD6 can be acutely injected in the lesioned spinal cord without inducing further damage, showing a widespread distribution covering all lesioned areas with a single injection and facilitating the formation of a slow-degrading porous scaffold at the lesion site that allows for the infiltration and/or proliferation of endogenous cells with no signs of collapse and without inducing further microglial and astroglial reactivity, as well as even reducing SCI-associated fibrosis. Altogether, these observations suggest that (EIS)2-RGD6—and, by extension, SELPs—could be promising polymers for the design of therapeutic strategies for SCI treatment.
      Instituto de Salud Carlos III y Fondo Europeo de Desarrollo Regional (FEDER) - (grant DTS19/00129 and DTS19/00162)
      Ministerio de Ciencia e Innovación, Agencia Estatal de Investigación - (grant 10.13039/501100011033 y PID2019-106386RB-I00)
      Fondo Europeo de Desarrollo Regional (FEDER) - (Grant RTI2018-097775-BI00)
      Junta de Comunidades de Castilla-La Mancha y Fondo Europeo de Desarrollo Regional (FEDER) - (Grant SBPLY/19/180501/000275)
      Junta de Comunidades de Castilla-La Mancha - (Grant II-2020/03)
      Ministerio de Ciencia e Innovación - (Grant BES-2017-082345)
    • الموضوع:
      Spinal cord - Diseases; Spinal cord - Wounds and injuries; Médula espinal - Enfermedades; Médula espinal - Lesiones y heridas; Polymers in medicine; Polímeros en medicina; Biomedical materials; Materiales biomédicos; Biomateriales; 32 Ciencias Médicas; 2403 Bioquímica; 3312 Tecnología de Materiales; info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion
    • Availability:
      Open access content. Open access content
      Atribución 4.0 Internacional
      info:eu-repo/semantics/openAccess
      http://creativecommons.org/licenses/by/4.0
      © 2022 The Authors
    • Note:
      application/pdf
      English
    • Other Numbers:
      ESUDE oai:uvadoc.uva.es:10324/60407
      https://doi.org/10.3390/pharmaceutics14122713
      Pharmaceutics, 2022, Vol. 14, Nº. 12, 2713
      1999-4923
      https://uvadoc.uva.es/handle/10324/60407
      2713
      12
      Pharmaceutics
      14
      1999-4923
      1456703140
    • Contributing Source:
      UNIVERSIDAD DE VALLADOLID
      From OAIster®, provided by the OCLC Cooperative.
    • الرقم المعرف:
      edsoai.on1456703140
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