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Altered mitochondrial Ca2+ uptake in presynaptic terminals of cultured striatal and cortical neurons from the zQ175 knock-in mouse model of Huntington's disease

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اقرأ أكثر حفظ في قائمتي
  • المؤلفون: Yoo, Hanna; Park, Hyokeun
  • نوع التسجيلة:
    Electronic Resource
  • الدخول الالكتروني :
    http://repository.hkust.edu.hk/ir/Record/1783.1-137837
    https://doi.org/10.1016/j.bbrc.2024.150010
    http://lbdiscover.ust.hk/uresolver?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rfr_id=info:sid/HKUST:SPI&rft.genre=article&rft.issn=0006-291X&rft.volume=&rft.issue=&rft.date=2024&rft.spage=&rft.aulast=Yoo&rft.aufirst=Hanna&rft.atitle=Altered+mitochondrial+Ca2%2B+uptake+in+presynaptic+terminals+of+cultured+striatal+and+cortical+neurons+from+the+zQ175+knock-in+mouse+model+of+Huntington%27s+disease&rft.title=Biochemical+and+Biophysical+Research+Communications
    http://www.scopus.com/record/display.url?eid=2-s2.0-85191995835&origin=inward
    http://gateway.isiknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=LinksAMR&SrcApp=PARTNER_APP&DestLinkType=FullRecord&DestApp=WOS&KeyUT=001239062900001
  • معلومة اضافية
    • Publisher Information:
      Elsevier B.V. 2024
    • نبذة مختصرة :
      Calcium (Ca2+) in mitochondria plays crucial roles in neurons including modulating metabolic processes. Moreover, excessive Ca2+ in mitochondria can lead to cell death. Thus, altered mitochondrial Ca2+ regulation has been implicated in several neurodegenerative diseases including Huntington's disease (HD). HD is a progressive hereditary neurodegenerative disorder that results from abnormally expanded cytosine-adenine-guanine trinucleotide repeats in the huntingtin gene. One neuropathological hallmark of HD is neuronal loss in the striatum and cortex. However, mechanisms underlying selective loss of striatal and cortical neurons in HD remain elusive. Here, we measured the basal Ca2+ levels and Ca2+ uptake in single presynaptic mitochondria during 100 external electrical stimuli using highly sensitive mitochondria-targeted Ca2+ indicators in cultured cortical and striatal neurons of a knock-in mouse model of HD (zQ175 mice). We observed elevated presynaptic mitochondrial Ca2+ uptake during 100 electrical stimuli in HD cortical neurons compared with wild-type (WT) cortical neurons. We also found the highly elevated presynaptic mitochondrial basal Ca2+ level and Ca2+ uptake during 100 stimuli in HD striatal neurons. The elevated presynaptic mitochondrial basal Ca2+ level in HD striatal neurons and Ca2+ uptake during stimulation in HD striatal and cortical neurons can disrupt neurotransmission and induce mitochondrial Ca2+ overload, eventually leading to neuronal death in the striatum and cortex of HD. © 2024 Elsevier Inc.
    • الموضوع:
      Calcium; Homeostasis; Huntington's disease; Mitochondria; Neurodegeneration; Neurodegenerative disease; Article
    • Availability:
      Open access content. Open access content
    • Note:
      English
    • Other Numbers:
      HNK oai:repository.hkust.edu.hk:1783.1-137837
      Biochemical and Biophysical Research Communications, v. 716, July 2024, article number 150010
      0006-291X
      1090-2104
      1452721502
    • Contributing Source:
      HONG KONG UNIV OF SCI & TECH, THE
      From OAIster®, provided by the OCLC Cooperative.
    • الرقم المعرف:
      edsoai.on1452721502
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