The outcomes measured and reported in intracranial meningioma clinical trials: A systematic review

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المؤلفون: Millward, Christopher P;Millward, Christopher P; Keshwara, Sumirat M; Armstrong, Terri S; Armstrong, Terri S; Barrington, Heather; Barrington, Heather; Bell, Sabrina; Brodbelt, Andrew R; Bulbeck, Helen; Dirven, Linda; Dirven, Linda; Grundy, Paul L; Islim, Abdurrahman I; Javadpour, Mohsen; Koszdin, Shelli D; Marson, Anthony G; McDermott, Michael W; Meling, Torstein R; Oliver, Kathy; Plaha, Puneet; Preusser, Matthias; Preusser, Matthias; Santarius, Thomas; Srikandarajah, Nisaharan; Srikandarajah, Nisaharan; Taphoorn, Martin J B; Taphoorn, Martin J B; Turner, Carole; Watts, Colin; Watts, Colin; Weller, Michael; Weller, Michael; Williamson, Paula R; Zadeh, Gelareh; Zadeh, Gelareh; Zamanipoor Najafabadi, Amir H; Jenkinson, Michael D; Aldape, Kenneth; Aldape, Kenneth; et al
المصدر:
Millward, Christopher P; Keshwara, Sumirat M; Armstrong, Terri S; Barrington, Heather; Bell, Sabrina; Brodbelt, Andrew R; Bulbeck, Helen; Dirven, Linda; Grundy, Paul L; Islim, Abdurrahman I; Javadpour, Mohsen; Koszdin, Shelli D; Marson, Anthony G; McDermott, Michael W; Meling, Torstein R; Oliver, Kathy; Plaha, Puneet; Preusser, Matthias; Santarius, Thomas; Srikandarajah, Nisaharan; Taphoorn, Martin J B; Turner, Carole; Watts, Colin; Weller, Michael; Williamson, Paula R; Zadeh, Gelareh; Zamanipoor Najafabadi, Amir H; Jenkinson, Michael D; Aldape, Kenneth; et al (2024). The outcomes measured and reported in intracranial meningioma clinical trials: A systematic review. Neuro-oncology advances, 6(1):vdae030.
نوع التسجيلة:
Electronic Resource
الدخول الالكتروني :
https://www.zora.uzh.ch/id/eprint/260265/
https://www.zora.uzh.ch/id/eprint/260265
10.1093/noajnl/vdae030

معلومة اضافية
- Publisher Information:
  Oxford University Press 2024-03-02
- نبذة مختصرة :
  Background Meningioma clinical trials have assessed interventions including surgery, radiotherapy, and pharmacotherapy. However, agreement does not exist on what, how, and when outcomes of interest should be measured. To do so would allow comparative analysis of similar trials. This systematic review aimed to summarize the outcomes measured and reported in meningioma clinical trials. Methods Systematic literature and trial registry searches were performed to identify published and ongoing intracranial meningioma clinical trials (PubMed, Embase, Medline, CINAHL via EBSCO, and Web of Science, completed January 22, 2022). Reported outcomes were extracted verbatim, along with an associated definition and method of measurement if provided. Verbatim outcomes were deduplicated and the resulting unique outcomes were grouped under standardized outcome terms. These were classified using the taxonomy proposed by the “Core Outcome Measures in Effectiveness Trials” (COMET) initiative. Results Thirty published articles and 18 ongoing studies were included, describing 47 unique clinical trials: Phase 2 n = 33, phase 3 n = 14. Common interventions included: Surgery n = 13, radiotherapy n = 8, and pharmacotherapy n = 20. In total, 659 verbatim outcomes were reported, of which 84 were defined. Following de-duplication, 415 unique verbatim outcomes remained and were grouped into 115 standardized outcome terms. These were classified using the COMET taxonomy into 29 outcome domains and 5 core areas. Conclusions Outcome measurement across meningioma clinical trials is heterogeneous. The standardized outcome terms identified will be prioritized through an eDelphi survey and consensus meeting of key stakeholders (including patients), in order to develop a core outcome set for use in future meningioma clinical trials.
- الموضوع:
  Clinic for Neurology; 610 Medicine & health; Journal Article; PeerReviewed; info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion
- Note:
  application/pdf
  info:doi/10.5167/uzh-260265
  English
  English
- Other Numbers:
  CHUZH oai:www.zora.uzh.ch:260265
  https://www.zora.uzh.ch/id/eprint/260265/1/ZORA_download.pdf
  info:doi/10.5167/uzh-260265
  info:doi/10.1093/noajnl/vdae030
  info:pmid/38596717
  urn:issn:2632-2498
  1443059222
- Contributing Source:
  HAUPTBIBLIOTHEK UNIV OF ZURICH
  From OAIster®, provided by the OCLC Cooperative.
- الرقم المعرف:
  edsoai.on1443059222

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The outcomes measured and reported in intracranial meningioma clinical trials: A systematic review

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