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HLA in North Colombia Chimila Amerindians

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  • معلومة اضافية
    • Publisher Information:
      Elsevier 2024-01-11T12:11:24Z 2024-01-11T12:11:24Z 2018-04-13
    • نبذة مختصرة :
      HLA-A,-B,-C,-DRB1 and -DQB1 alleles have been studied in Chimila Amerindians from Sabana de San Angel (North Colombian Coast) by using high resolution molecular typing. A frequent extended haplotype was found:HLA-A*24:02-B*51:10-C*15:02-BRB1*04:07-DQB1*03:02 (28.7%) which has also been described in Amerinndian Mayos Mexican population (Mexico, California Gulf, Pacific Ocean). Other haplotypes had already been found in Amerindians from Mexico (Pacific and Atlantic Coast), Peru (highlands and Amazon Basin), Bolivia and North USA. A geographic pattern according to HLA allele or haplotype frequencies is lacking in Amerindians, as already known. Also, five new extended haplotypes were found in Chimila Amerindians. Their HLA-A*24:02 high frequencies characteristic is shared with aboriginal populations of Taiwan; also, HLA-C*01:02 high frequencies are found in New Zealand Maoris, New Caledonians and Kimberly Aborigines from Australia. Finally, this study may show a model of evolutionary factors acting and rising one HLA allele frequency (-A*24:02), but not in others that belong to the same or different HLA loci.
      Unión Europea
      Ministerio de Economía, Comercio y Empresa
      Depto. de Inmunología, Oftalmología y ORL
      Fac. de Medicina
      TRUE
      pub
    • الموضوع:
      612.017; HLA; Chimila; Evolution; Amerindians; Pacific Ocean; America; Wiwa; Lakota-Sioux; Mayas; Mayos; Huastec; Teeneks; Aztecs; Nahuas; Jaidukama; Quechuas; Aymaras; Lamas; Tarahumaras; Uros; Inmunología; 2412 Inmunología; journal article
    • Availability:
      Open access content. Open access content
      embargoed access
    • Note:
      application/pdf
      0198-8859
      English
    • Other Numbers:
      ESRCM oai:docta.ucm.es:20.500.14352/92521
      Arnaiz-Villena A, Palacio-Grüber J, Juarez I, Hernández E, Muñiz E, Bayona B, Campos C, Nieto J, Martin-Villa M, Silvera C. HLA in North Colombia Chimila Amerindians. Hum Immunol. 2018 Apr;79(4):189-190. doi: 10.1016/j.humimm.2018.02.004
      0198-8859
      10.1016/j.humimm.2018.02.004
      1429622849
    • Contributing Source:
      REPOSITORIO E-PRINTS UNIVERSIDAD COMPLU
      From OAIster®, provided by the OCLC Cooperative.
    • الرقم المعرف:
      edsoai.on1429622849
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