Body mass index and weight gain in pregnancy and cardiovascular health in middle age : A cohort study

Umeå universitet, Allmänmedicin Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden; Department Physical Education, Sport and Human Motricity, Universidad Autónoma de Madrid, Madrid, Spain Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden; Centre for Epidemiology and Community Medicine, Region Stockholm, Stockholm, Sweden; Center for Wellbeing, Welfare and Happiness, Stockholm School of Economics, Stockholm, Sweden School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden Department for Clinical Sciences in Malmö, Centre for Primary Health Care Research, Lund University, Lund, Sweden Clinical Epidemiology Unit, Department of Medical Sciences, Uppsala University, Uppsala, Sweden; The George Institute for Global Health, University of New South Wales, NSW, Sydney, Australia Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden; Centre for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden; The George Institute for Global Health, University of New South Wales, NSW, Sydney, Australia Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden 2024

Objective: To examine associations between body mass index (BMI) in early pregnancy and gestational weight gain (GWG) with cardiovascular health in middle age using the ‘Life's Essential 8’ (LE8) concept of the American Heart Association (AHA). Design: Population-based cohort study. Setting: Swedish CardioPulmonary bioImage Study (SCAPIS). Population: A total of 8871 women from SCAPIS were included. Methods: Information on cardiovascular health in middle age was collected from SCAPIS and linked to pregnancy weight data obtained from the Swedish Medical Birth Register, with an average follow-up time of 24.5 years. An LE8 score between 0 and 100 was determined, where a score under 60 points was defined as poor cardiovascular health. Binary logistic regression and restricted cubic splines were used. Main outcome measures: Cardiovascular health according to LE8 in middle age. Results: The odds of having poor cardiovascular health in middle age were significantly higher in women who had overweight (adjusted odds ratio, aOR 3.30, 95% CI 2.82–3.88) or obesity (aOR 7.63, 95% CI 5.86–9.94), compared with women classified as being of normal weight in pregnancy. Higher odds were also found for excessive GWG (aOR 1.31, 95% CI 1.09–1.57), compared with women who gained weight within the recommendations. Conclusions: A high BMI in early pregnancy and excessive GWG were associated with greater odds of poor cardiovascular health in middle age. Although further studies are needed, our results highlight pregnancy as an important period to support long-term cardiovascular health.

body mass index; gestational weight gain; Life's Essential 8; pregnancy; pregnancy as a window for future health; Obstetrics, Gynecology and Reproductive Medicine; Reproduktionsmedicin och gynekologi; Public Health, Global Health, Social Medicine and Epidemiology; Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi; Article in journal; info:eu-repo/semantics/article; text

10.1111.1471-0528.17740

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UPE oai:DiVA.org:umu-219064
0000-0002-1617-6102
doi:10.1111/1471-0528.17740
PMID 38149523
ISI:001132907500001
Scopus 2-s2.0-85180848848
1428112811

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