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Nippostrongylus brasiliensis in the rat: failure to relate intestinal histamine and mast cell levels with worm expulsion

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اقرأ أكثر حفظ في قائمتي
  • المؤلفون: Keller, R
  • المصدر:
    Keller, R (1971). Nippostrongylus brasiliensis in the rat: failure to relate intestinal histamine and mast cell levels with worm expulsion. Parasitology, 63(3):473-481.
  • نوع التسجيلة:
    Electronic Resource
  • الدخول الالكتروني :
    https://www.zora.uzh.ch/id/eprint/154520/
    https://www.zora.uzh.ch/id/eprint/154520
    10.1017/s0031182000079993
  • معلومة اضافية
    • Publisher Information:
      Cambridge University Press 1971-12-01
    • نبذة مختصرة :
      This paper describes experiments to determine whether intestinal tissue mast cells and/or intestinal histamine are involved in the second, expulsive step of worm elimination. In neonatal rats, intestinal tissue contains only very little histamine and mature mast cells are encountered only sporadically. From birth to the adult age, there was a gradual rise in both intestinal mast cells and histamine. During Nippostrongylus brasiliensis infection in the adult rat, the concentration of histamine in the small intestine was clearly lower than in uninfected controls.Especially low histamine values were found to occur on days 6-12 of a primary infection in the region where the main worm burden was located. Similarly, the number of tissue mast cells present in the epithelium of the jejunum was decreased in the same region and during the same period of time. From the observation that the bulk of the parasites are expelled at a time when histamme and mast cell levels are low, it was concluded that mast cells and their constituents were not an essential factor in the second step of worm elimination This work was supported by the Schweizerische Nationalfonds zur Förderung der wissenschaftlichen Forschung (Grant 5200.3). The skilful technical assistance of Miss I. Beeger, Miss R. Keist and Miss M. Iseli is gratefully acknowledged. I thank Mr H. Berchtold, Biostatistisches Zentrum der Universität Zürich, for the statistical evaluation of the data
    • الموضوع:
      142-005; 570 Life sciences; biology; 610 Medicine & health; 600 Technology; Journal Article; PeerReviewed; info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion
    • Availability:
      Open access content. Open access content
      info:eu-repo/semantics/openAccess
      info:eu-repo/semantics/openAccess
    • Note:
      application/pdf
      info:doi/10.5167/uzh-154520
      English
      English
    • Other Numbers:
      CHUZH oai:www.zora.uzh.ch:154520
      https://www.zora.uzh.ch/id/eprint/154520/1/ZORA_NL_154520.pdf
      info:doi/10.5167/uzh-154520
      info:doi/10.1017/s0031182000079993
      info:pmid/5139027
      urn:issn:0031-1820
      1416167003
    • Contributing Source:
      HAUPTBIBLIOTHEK UNIV OF ZURICH
      From OAIster®, provided by the OCLC Cooperative.
    • الرقم المعرف:
      edsoai.on1416167003
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