Self-Immolative Polymers as novel pH-responsive gate keepers for drug delivery

Royal Society of Chemistry 2023-06-17T21:49:18Z 2023-06-17T21:49:18Z 2016-12-07

RESEARCHER ID M-3378-2014 (María Vallet Regí) ORCID 0000-0002-6104-4889 (María Vallet Regí)
A novel pH-sensitive nanocarrier based on mesoporous silica nanoparticles with self-immolative polymers blocking the pore openings is presented. Triggered release by acid pH is demonstrated, together with their in vitro biocompatibility and effective cell internalisation, which makes this new material a promising candidate for future applications in cancer treatment.
Unión Europea. H2020
European Research Council
Ministerio de Economía y Competitividad (MINECO)
Depto. de Química en Ciencias Farmacéuticas
Fac. de Farmacia
TRUE
inpress

66; 546; 615.46; Biomaterials; Polymers; Materiales biomédicos; Polímeros; Materiales; Química inorgánica (Química); 3312 Tecnología de Materiales; 2303 Química Inorgánica; journal article

Open access content. Open access content
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es
open access

application/pdf
2046-2069
English

ESRCM oai:docta.ucm.es:20.500.14352/17591
1 O. C. Farokhzad and R. Langer, ACS Nano, 2009, 3, 16–20. 2 J. D. Byrne, T. Betancourt and L. Brannon-Peppas, Adv. Drug Deliv. Rev., 2008, 60, 1615–1626. 3 S. Mura, J. Nicolas and P. Couvreur, Nat. Mater., 2013, 12, 991–1003. 4 R. Misra, S. Acharya and S. K. Sahoo, Drug Discov. Today, 2010, 15, 842–850. 5 A. Baeza, M. Manzano, M. Colilla and M. Vallet-regí, Biomater. Sci., 2016, 4, 803–813. 6 F. Tang, L. Li and D. Chen, Adv. Mater., 2012, 24, 1504–1534. 7 Z. Li, J. C. Barnes, A. Bosoy, J. F. Stoddart and J. I. Zink, Chem. Soc. Rev., 2012, 41, 2590. 8 C. E. Ashley, E. C. Carnes, G. K. Phillips, D. Padilla, P. N. Durfee, P. a Brown, T. N. Hanna, J. Liu, B. Phillips, M. B. Carter, N. J. Carroll, X. Jiang, D. R. Dunphy, C. L. Willman, D. N. Petsev, D. G. Evans, A. N. Parikh, B. Chackerian, W. Wharton, D. S. Peabody and C. J. Brinker, Nat. Mater., 2011, 10, 389–397. 9 I. I. Slowing, J. L. Vivero-Escoto, B. G. Trewyn and V. S.-Y. Lin, J. Mater. Chem., 2010, 20, 7924–7937. 10 M. Manzano and M. Vallet-Regí, J. Mater. Chem., 2010, 20, 5593. 11 B. G. Trewyn, I. I. Slowing, S. Giri, H. Chen and V. S. Lin, Acc. Chem. Res., 2007, 40, 846–853. 12 J. L. Vivero-Escoto, I. I. Slowing, B. G. Trewyn and V. S.-Y. Lin, Small, 2010, 6, 1952–1967. 13 C. Argyo, V. Weiss, C. Bräuchle and T. Bein, Chem. Mater., 2014, 26, 435– 451. 14 Y. Zhang, Z. Zhi, T. Jiang, J. Zhang, Z. Wang and S. Wang, J. Control. Release, 2010, 145, 257–263. 15 A. Baeza, M. Colilla and M. Vallet-Regí, Expert Opin. Drug Deliv., 2015, 12, 319–337. 16 T. Kolter and K. Sandhoff, FEBS Lett., 2010, 584, 1700–1712. 17 Z. Li, H. Li, L. Liu, X. You, C. Zhang and Y. Wang, RSC Adv., 2015, 5, 77097– 77105. 18 Y. Yan, J. Fu, X. Liu, T. Wang and X. Lu, RSC Adv., 2015, 5, 30640–30646. 19 A. Sagi, R. Weinstain, N. Karton and D. Shabat, J. Am. Chem. Soc., 2008, 8, 5434–5435. 20 W. Wang and C. Alexander, Angew. Chemie - Int. Ed., 2008, 47, 7804–7806. 21 S. Gnaim and D. Shabat, Acc. Chem. Res., 2014, 47, 2970–2984. 22 R. A. McBride and
2046-2069
10.1039/C6RA26771H
1413947716

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