Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Temperature-Sensitive Hydrogels as Carriers for Modulated Delivery of Acetaminophen

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
اقرأ أكثر حفظ في قائمتي
  • المصدر:
    Gels
  • نوع التسجيلة:
    Electronic Resource
  • الدخول الالكتروني :
    http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6664
    http://TechnoRep.tmf.bg.ac.rs/bitstream/id/18003/Temperature_Sensitive_Hydrogels_pub_2023.pdf
    info:eu-repo/grantAgreement/MESTD/inst-2020/200133/RS
    info:eu-repo/grantAgreement/MESTD/inst-2020/200134/RS
  • معلومة اضافية
    • Publisher Information:
      MDPI 2023
    • Added Details:
      Ilić-Stojanović, Snežana
      Nikolić, Ljubiša
      Nikolić, Vesna
      Ristić, Ivan
      Cakić, Suzana
      Petrović, Slobodan D.
    • نبذة مختصرة :
      The purposes of this study are the polymerization of temperature-sensitive copolymers based on N-isopropyl acrylamide and 10 mol % of 2-hydroxypropylmethacrylate, characterisations of their thermal, morphological and swelling properties, as well as the analysis of potential application in drug-delivery systems. Acetaminophen, the representative of non-steroidal anti-inflammatory drugs, was used as a model drug in this study. It is a common pain relief drug, which is also used for fever treatment. However, oral administration comes with certain health risks, mainly the overdose and frequent administration of up to four times a day. The goal of applying temperature-sensitive hydrogel is to enable extended administration once a day, depending on the body temperature. The swelling behavior of the obtained poly(N-isopropyl acrylamide-co-2-hydroxypropylmethacrylate) (p(NIPA/HPMA)) hydrogels and their temperature-sensitivity, kinetics and order of swelling processes at 18 and 38 °C were analyzed. The thermal properties of these hydrogels were observed by the DSC method, and the obtained thermograms showed both melting and glass transitions. The drug delivery system of p(NIPA/HPMA) hydrogels with loaded acetaminophen was analyzed using scanning electron microscopy and Fourier transform infrared spectroscopy methods. Structural analysis of FTIR spectra indicates that non-covalent intermolecular interactions of the type of hydrogen bonds were formed among functional groups of acetaminophen and side-chains of p(NIPA/HPMA) hydrogels. The surface structure of p(NIPA/HPMA) hydrogels after drug loading indicates the acetaminophen presence into the pores of the hydrogel network, and their loading efficiency was higher than 92%. Qualitative and quantitative analysis of acetaminophen, determined by the high-pressure liquid chromatography method, showed that about 90–99% of the loaded amount was released from p(NIPA/HPMA) hydrogels within 24 h. Kinetic parameters of the acetaminophen
    • الموضوع:
      2-hydroxypropylmethacrylate; acetaminophen; drug carrier; DSC; hydrogels; modulated drug release; N-isopropyl acrylamide; article
    • Note:
      Gels
      English
    • Other Numbers:
      RSPST oai:TechnoRep.tmf.bg.ac.rs:123456789/6664
      2310-2861
      10.3390/gels9090684
      2-s2.0-85172233842
      1405288938
    • Contributing Source:
      UIVERSITY OF BELGRADE
      From OAIster®, provided by the OCLC Cooperative.
    • الرقم المعرف:
      edsoai.on1405288938
HoldingsOnline