Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Effect of Desmosterol, Lathosterol and Coprostanol on the phase behaviour of phospholipid membranes

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
اقرأ أكثر حفظ في قائمتي
  • المؤلفون: Kamal, Md Arif; Pal, Antara
  • نوع التسجيلة:
    Electronic Resource
  • الدخول الالكتروني :
    http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-62490
    Colloids and Surfaces A : Physicochemical and Engineering Aspects, 0927-7757, 2023, 673
  • معلومة اضافية
    • Publisher Information:
      Malmö universitet, Institutionen för biomedicinsk vetenskap (BMV) Malmö universitet, Biofilms Research Center for Biointerfaces Raman Res Inst, C V Raman Ave, Bangalore 560080, Karnataka, India Raman Res Inst, C V Raman Ave, Bangalore 560080, Karnataka, India.;Stockholm Univ, Dept Phys, Stockholm, Sweden.;MAX IV Lab, Lund, Sweden. 2023
    • نبذة مختصرة :
      Sterols have played an important role in membrane evolution. The effect of these molecules, particularly the naturally occurring ones, such as cholesterol, ergosterol, lanosterol, phytosterols and oxysterols on the prop-erties of lipid model membranes have been extensively investigated. Unfortunately, other naturally occurring sterols such as desmosterol and lathosterol have received very little attention. Using small angle X-ray scattering (SAXS), we have carried out detailed investigations on the influence of desmosterol and lathosterol along with coprostanol on the phase behaviour of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) membranes. SAXS results indicate both that these sterols modulate the properties of the DPPC bilayer in a manner similar to cholesterol. However, we have found desmosterol to be more efficient than cholesterol in suppressing the main transition of DPPC, with the fluid phase stabilized at around 15 mol% (compared to around 20 mol% in cholesterol). Coprostanol on the other hand was found to be less efficient in stabilizing the fluid phase than the other two. The results obtained from our study in combination with those existing in the literature will help in establishing a complete picture of how different sterols influence the properties of lipid membranes.
    • الموضوع:
      Desmosterol; Lathosterol; Coprostanol; SAXS; Phase behaviour; DPPC; Physical Chemistry; Fysikalisk kemi; Article in journal; info:eu-repo/semantics/article; text
    • الرقم المعرف:
      10.1016.j.colsurfa.2023.131489
    • Note:
      application/pdf
      English
    • Other Numbers:
      UPE oai:DiVA.org:mau-62490
      0000-0001-5585-2065
      doi:10.1016/j.colsurfa.2023.131489
      ISI:001053802200001
      Scopus 2-s2.0-85162187595
      1399556509
    • Contributing Source:
      UPPSALA UNIV LIBR
      From OAIster®, provided by the OCLC Cooperative.
    • الرقم المعرف:
      edsoai.on1399556509
HoldingsOnline