Publisher Information: Uppsala universitet, Institutionen för folkhälso- och vårdvetenskap Uppsala universitet, Livsstil och rehabilitering vid långvarig sjukdom Norwegian Sch Sport Sci, Dept Phys Performance, Oslo, Norway.;Norwegian Sch Sport Sci, Dept Phys Performance, Sognsveien 220, N-0863 Oslo, Norway Haukeland Hosp, Canc Ctr Educ & Rehabil, Dept Oncol & Med Phys, Bergen, Norway Haukeland Hosp, Canc Ctr Educ & Rehabil, Dept Oncol & Med Phys, Bergen, Norway Univ Agder, Dept Sport Sci & Phys Educ, Kristiansand, Norway Univ Agder, Dept Sport Sci & Phys Educ, Kristiansand, Norway Norwegian Sch Sport Sci, Dept Phys Performance, Oslo, Norway.;Univ Agder, Dept Sport Sci & Phys Educ, Kristiansand, Norway JMIR Publications Inc. 2022
نبذة مختصرة : Background: (Neo-)adjuvant chemotherapy for breast cancer is effective but has deleterious side effects on muscle tissue, resulting in reduced skeletal muscle mass, muscle function, and cardiorespiratory fitness. Various exercise regimens during cancer treatment have been shown to counteract some of these side effects. However, no study has compared the effect of high-intensity training versus low-to-moderate intensity training on muscle tissue cellular outcomes and physical function in patients with breast cancer during chemotherapy. Objective: The aim of this substudy within the Physical Training in Cancer (Phys-Can) consortium is to evaluate and compare the effects of high and low-to-moderate intensity exercise on muscle cellular outcomes, muscle function, and cardiorespiratory fitness in women with breast cancer undergoing (neo-)adjuvant chemotherapy. We further aim to investigate if the effects of chemotherapy including taxanes on muscles will be different from those of taxane-free chemotherapy. Methods: Eighty women recently diagnosed with breast cancer scheduled to start (neo-)adjuvant chemotherapy will be randomized to a combination of strength and endurance training, either at high intensity or at low-to-moderate intensity. Testing of muscle function and cardiorespiratory fitness and collection of muscle biopsies from the vastus lateralis muscle will be performed before the first cycle of chemotherapy (or after 1 week, when not possible) (T0), halfway through chemotherapy (T1), and after completion of chemotherapy (T2). It is estimated that approximately 50% of the participants will be willing to undergo muscle biopsies. To separate the effect of the treatment itself, a usual care group with no supervised training will also be included, and in this group, testing and collection of muscle biopsies will be performed at T0 and T2 only. Results: This study is funded by Active Against Cancer (Aktiv mot kreft) (May 2013) and the Norwegian Cancer Society (December
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