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Herpes Simplex Virus Type 1 Induces AD-like Neurodegeneration Markers in Human Progenitor and Differentiated ReNcell VM Cells

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  • نوع التسجيلة:
    Electronic Resource
  • الدخول الالكتروني :
    http://hdl.handle.net/10261/310500
    https://doi.org/10.3390/microorganisms11051205
    Publisher's version
    https://doi.org/10.3390/microorganisms11051205
    Sí
    info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-113921RB-I00/ES/HOMEOSTASIS DE COLESTEROL Y VIA LISOSOMAL EN LA NEURODEGENERACION INDUCIDA POR HSV-1 Y EN LA ENFERMEDAD DE ALZHEIMER: MECANISMOS PATOGENICOS Y BIOMARCADORES
  • معلومة اضافية
    • Publisher Information:
      Multidisciplinary Digital Publishing Institute 2023-05
    • Added Details:
      Ministerio de Ciencia, Innovación y Universidades (España)
      Agencia Estatal de Investigación (España)
      Ministerio de Universidades (España)
      Salgado, Blanca
      Sastre, Isabel
      Bullido, María Jesús
      Aldudo, Jesús
    • نبذة مختصرة :
      An increasing body of evidence strongly suggests that infections or reactivations of herpes simplex virus type 1 (HSV-1) may be closely linked to Alzheimer’s disease (AD). Promising results have been obtained using cell and animal models of HSV-1 infection, contributing to the understanding of the molecular mechanisms linking HSV-1 infection and AD neurodegeneration. ReNcell VM is a human neural stem cell line that has been used as a model system to study the impact of various infectious agents on the central nervous system. In this study, we demonstrate the suitability of the ReNcell VM cell line for developing a new in vitro model of HSV-1 infection. By following standard differentiation protocols, we were able to derive various nervous cell types, including neurons, astrocytes, and oligodendrocytes, from neural precursors. Additionally, we demonstrated the susceptibility of ReNcell VM cells, including precursor and differentiated cells, to HSV-1 infection and subsequent viral-induced AD-like neurodegeneration. Our findings support the use of this cell line to generate a new research platform for investigating AD neuropathology and its most significant risk factors, which may lead to important discoveries in the context of this highly impactful disease.
    • الموضوع:
      Alzheimer’s disease; HSV-1; ReNcell VM; Differentiation; Infection; Neurodegeneration; Lysosome alterations; Neurons; Glial cells; artículo
    • Note:
      English
    • Other Numbers:
      CTK oai:digital.csic.es:10261/310500
      Microorganisms 11(5): 1205 (2023)
      10.3390/microorganisms11051205
      2076-2607
      1395196894
    • Contributing Source:
      CSIC
      From OAIster®, provided by the OCLC Cooperative.
    • الرقم المعرف:
      edsoai.on1395196894
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