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Adipocytes Encapsulating Telratolimod Recruit and Polarize Tumor-Associated Macrophages for Cancer Immunotherapy.

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  • معلومة اضافية
    • Publisher Information:
      eScholarship, University of California 2023-02-01
    • نبذة مختصرة :
      Tumor-associated adipocytes (TAAs) recruit monocytes and promote their differentiation into tumor-associated macrophages (TAMs) that support tumor development. Here, TAAs are engineered to promote the polarization of TAMs to the tumor suppressive M1 phenotype. Telratolimod, a toll-like receptor 7/8 agonist, is loaded into the lipid droplets of adipocytes to be released at the tumor site upon tumor cell-triggered lipolysis. Locally administered drug-loaded adipocytes increased tumor suppressive M1 macrophages in both primary and distant tumors and suppressed tumor growth in a melanoma model. Furthermore, drug-loaded adipocytes improved CD8+ T cell-mediated immune responses within the tumor microenvironment and favored dendritic cell maturation in the tumor draining lymph nodes.
    • الموضوع:
    • Availability:
      Open access content. Open access content
      public
    • Note:
      application/pdf
      Advanced science (Weinheim, Baden-Wurttemberg, Germany) vol 10, iss 5, e2206001 2198-3844
    • Other Numbers:
      CDLER oai:escholarship.org:ark:/13030/qt0k97v2fx
      qt0k97v2fx
      https://escholarship.org/uc/item/0k97v2fx
      https://escholarship.org/
      1391581730
    • Contributing Source:
      UC MASS DIGITIZATION
      From OAIster®, provided by the OCLC Cooperative.
    • الرقم المعرف:
      edsoai.on1391581730
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