Adipocytes Encapsulating Telratolimod Recruit and Polarize Tumor-Associated Macrophages for Cancer Immunotherapy.

eScholarship, University of California 2023-02-01

Tumor-associated adipocytes (TAAs) recruit monocytes and promote their differentiation into tumor-associated macrophages (TAMs) that support tumor development. Here, TAAs are engineered to promote the polarization of TAMs to the tumor suppressive M1 phenotype. Telratolimod, a toll-like receptor 7/8 agonist, is loaded into the lipid droplets of adipocytes to be released at the tumor site upon tumor cell-triggered lipolysis. Locally administered drug-loaded adipocytes increased tumor suppressive M1 macrophages in both primary and distant tumors and suppressed tumor growth in a melanoma model. Furthermore, drug-loaded adipocytes improved CD8+ T cell-mediated immune responses within the tumor microenvironment and favored dendritic cell maturation in the tumor draining lymph nodes.

Adipocytes; Macrophages; Humans; Melanoma; Immunotherapy; Tumor Microenvironment; Tumor-Associated Macrophages; adipocyte; cancer immunotherapy; drug delivery; macrophage; Cancer; article

Open access content. Open access content
public

application/pdf
Advanced science (Weinheim, Baden-Wurttemberg, Germany) vol 10, iss 5, e2206001 2198-3844

CDLER oai:escholarship.org:ark:/13030/qt0k97v2fx
qt0k97v2fx
https://escholarship.org/uc/item/0k97v2fx
https://escholarship.org/
1391581730

UC MASS DIGITIZATION
From OAIster®, provided by the OCLC Cooperative.

edsoai.on1391581730