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Adipocytes Encapsulating Telratolimod Recruit and Polarize Tumor-Associated Macrophages for Cancer Immunotherapy.
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- المؤلفون: Wen, Di; Wen, Di; Liang, Tingxizi; Chen, Guojun; Li, Hongjun; Wang, Zejun; Wang, Jinqiang; Fu, Ruxing; Han, Xiao; Ci, Tianyuan; Zhang, Yuqi; Abdou, Peter; Li, Ruoxin; Bu, Linlin; Dotti, Gianpietro; Gu, Zhen
- المصدر:
Advanced science (Weinheim, Baden-Wurttemberg, Germany); vol 10, iss 5, e2206001; 2198-3844
- نوع التسجيلة:
Electronic Resource
- الدخول الالكتروني :
https://escholarship.org/uc/item/0k97v2fx
https://escholarship.org/
- معلومة اضافية
- Publisher Information:
eScholarship, University of California 2023-02-01
- نبذة مختصرة :
Tumor-associated adipocytes (TAAs) recruit monocytes and promote their differentiation into tumor-associated macrophages (TAMs) that support tumor development. Here, TAAs are engineered to promote the polarization of TAMs to the tumor suppressive M1 phenotype. Telratolimod, a toll-like receptor 7/8 agonist, is loaded into the lipid droplets of adipocytes to be released at the tumor site upon tumor cell-triggered lipolysis. Locally administered drug-loaded adipocytes increased tumor suppressive M1 macrophages in both primary and distant tumors and suppressed tumor growth in a melanoma model. Furthermore, drug-loaded adipocytes improved CD8+ T cell-mediated immune responses within the tumor microenvironment and favored dendritic cell maturation in the tumor draining lymph nodes.
- الموضوع:
- Availability:
Open access content. Open access content
public
- Note:
application/pdf
Advanced science (Weinheim, Baden-Wurttemberg, Germany) vol 10, iss 5, e2206001 2198-3844
- Other Numbers:
CDLER oai:escholarship.org:ark:/13030/qt0k97v2fx
qt0k97v2fx
https://escholarship.org/uc/item/0k97v2fx
https://escholarship.org/
1391581730
- Contributing Source:
UC MASS DIGITIZATION
From OAIster®, provided by the OCLC Cooperative.
- الرقم المعرف:
edsoai.on1391581730
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