Defining left ventricular remodeling using lean body mass allometry: a UK Biobank study

Linköpings universitet, Avdelningen för diagnostik och specialistmedicin Linköpings universitet, Medicinska fakulteten Region Östergötland, Fysiologiska kliniken US Stanford Univ, CA 94304 USA; Stanford Univ, CA 94305 USA; Heidelberg Univ Hosp, Germany; Stanford Univ, CA 94304 USA Stanford Univ, CA 94304 USA; Stanford Univ, CA 94305 USA Univ Leuven, Belgium Univ Leuven, Belgium Stanford Univ, CA 94304 USA Stanford Univ, CA 94304 USA; Stanford Univ, CA 94305 USA Stanford Univ, CA 94304 USA Liverpool John Moores Univ, England Liverpool John Moores Univ, England Stanford Univ, CA 94304 USA; Stanford Univ, CA 94305 USA Stanford Univ, CA 94304 USA; Stanford Univ, CA 94305 USA Stanford Univ, CA 94304 USA; Stanford Univ, CA 94305 USA; Stanford Univ, CA 94304 USA SPRINGER 2023

Purpose The geometric patterns of ventricular remodeling are determined using indexed left ventricular mass (LVM), end-diastolic volume (LVEDV) and concentricity, most often measured using the mass-to-volume ratio (MVR). The aims of this study were to validate lean body mass (LBM)-based allometric coefficients for scaling and to determine an index of concentricity that is independent of both volume and LBM.Methods Participants from the UK Biobank who underwent both CMR and dual-energy X-ray absorptiometry (DXA) during 2014-2015 were considered (n = 5064). We excluded participants aged >= 70 years or those with cardiometabolic risk factors. We determined allometric coefficients for scaling using linear regression of the logarithmically transformed ventricular remodeling parameters. We further defined a multiplicative allometric relationship for LV concentricity (LVC) adjusting for both LVEDV and LBM.Results A total of 1638 individuals (1057 female) were included. In subjects with lower body fat percentage (< 25% in males, < 35% in females, n = 644), the LBM allometric coefficients for scaling LVM and LVEDV were 0.85 +/- 0.06 and 0.85 +/- 0.03 respectively (R-2 = 0.61 and 0.57, P < 0.001), with no evidence of sex-allometry interaction. While the MVR was independent of LBM, it demonstrated a negative association with LVEDV in (females: r = - 0.44, P < 0.001; males: - 0.38, P < 0.001). In contrast, LVC was independent of both LVEDV and LBM [LVC = LVM/(LVEDV0.40 x LBM0.50)] leading to increased overlap between LV hypertrophy and higher concentricity.Conclusions We validated allometric coefficients for LBM-based scaling for CMR indexed parameters relevant for classifying geometric patterns of ventricular remodeling.
Funding Agencies|Stanford Cardiovascular Institute; Deutsche Forschungsgemeinschaft (DFG-German Research Foundation) under the Walter-Benjamin Program; [GO 3196/3-1]; [707766-809341]

Ventricular remodeling; LV hypertrophy; Scaling; Allometry; Body composition; Adiposity; Obesity; Visceral fat; Sport and Fitness Sciences; Idrottsvetenskap; Article in journal; info:eu-repo/semantics/article; text

10.1007.s00421-022-05125-9

English

UPE oai:DiVA.org:liu-191173
0000-0002-3751-7180
doi:10.1007/s00421-022-05125-9
PMID 36617359
ISI:000911014700001
1387003359

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