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Prothrombin 3'end Gene Variants in Patients With Sporadic Colon Adenocarcinoma

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اقرأ أكثر حفظ في قائمتي
  • المصدر:
    Anticancer Research
  • نوع التسجيلة:
    Electronic Resource
  • الدخول الالكتروني :
    https://imagine.imgge.bg.ac.rs/handle/123456789/1219
    https://imagine.imgge.bg.ac.rs/bitstream/id/2700/Prothrombin_3_end_Gene_Variants_in_Patients_2019.pdf
    info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173008/RS
    Republic of Serbia
    Republic of Croatia
  • معلومة اضافية
    • Publisher Information:
      Int Inst Anticancer Research, Athens 2019
    • Added Details:
      Cumbo, Marija
      Tomić, Branko
      Dunjić Manevski, Sofija
      Jovanović, Tamara
      Gvozdenov, Maja
      Pruner, Iva
      Aralica, Gorana
      Kapitanović, Sanja
      Cacev, Tamara
      Đorđević, Valentina
    • نبذة مختصرة :
      Background/ Aim: Thrombin plays significant roles in various types of cancer. However, the expression levels of prothrombin, the thrombin precursor, in cancer remain unclear. Variants of the 3'end of the prothrombin gene lead to increased prothrombin expression. This study aimed to analyze prothrombin 3'end gene variants in colon tumor and adjacent normal tissue samples. Materials and Methods: The study group consisted of 93 patients suffering from colon adenocarcinoma. The 3'end of the prothrombin gene was analyzed by DNA sequencing. Results: Three variants, all previously associated with increased prothrombin expression were detected. Frequency of the FII 19911G allele was 46.77% and 47.85% in tumor and normal tissue, respectively. For the FII 20210A allele, the detected frequencies were 2.15% and 1.61%, respectively. The frequency of the FII c.1824T allele was 0.54% in both tissues. Four patients showed different genotypes in tumor and normal tissue. Conclusion: Prothrombin 3' end gene variants may play a role in colorectal cancer.
    • الموضوع:
      tumor; prothrombin; normal adjacent tissue; Colon adenocarcinoma; 3'end gene variants; article
    • Note:
      Anticancer Research
    • Other Numbers:
      RSPST oai:imagine.imgge.bg.ac.rs:123456789/1219
      0250-7005
      10.21873/anticanres.13814
      31704834
      2-s2.0-85074729699
      000496129100026
      1368249097
    • Contributing Source:
      UIVERSITY OF BELGRADE
      From OAIster®, provided by the OCLC Cooperative.
    • الرقم المعرف:
      edsoai.on1368249097
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