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High shear rate propulsion of acoustic microrobots in complex biological fluids

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  • معلومة اضافية
    • Publisher Information:
      American Association for the Advancement of Science (AAAS) International 2022
    • نبذة مختصرة :
      Untethered microrobots offer a great promise for localized targeted therapy in hard-to-access spaces in our body. Despite recent advancements, most microrobot propulsion capabilities have been limited to homogenous Newtonian fluids. However, the biological fluids present in our body are heterogeneous and have shear rate–dependent rheological properties, which limit the propulsion of microrobots using conventional designs and actuation methods. We propose an acoustically powered microrobotic system, consisting of a three-dimensionally printed 30-micrometer-diameter hollow body with an oscillatory microbubble, to generate high shear rate fluidic flow for propulsion in complex biofluids. The acoustically induced microstreaming flow leads to distinct surface-slipping and puller-type propulsion modes in Newtonian and non-Newtonian fluids, respectively. We demonstrate efficient propulsion of the microrobots in diverse biological fluids, including in vitro navigation through mucus layers on biologically relevant three-dimensional surfaces. The microrobot design and high shear rate propulsion mechanism discussed herein could open new possibilities to deploy microrobots in complex biofluids toward minimally invasive targeted therapy.
      Max Planck Society
    • الموضوع:
      Science and technology; Driven; Soft; Dynamics; Forces; Mucus; Journal Article; text/academic publication
    • Note:
      pdf
      English
    • Other Numbers:
      T9K oai:libdigitalcollections.ku.edu.tr:IR/10326
      IR03530.pdf
      2375-2548
      Aghakhani, Amirreza, Abdon Pena-Francesch, Ugur Bozuyuk, Hakan Cetin, Paul Wrede, and Metin Sitti. ""High Shear Rate Propulsion of Acoustic Microrobots in Complex Biological Fluids."" Science Advances. 8.10 (2022).
      WoS; Scopus; PubMed
      NA
      NA
      1360594364
    • Contributing Source:
      KOC UNIV LIBR
      From OAIster®, provided by the OCLC Cooperative.
    • الرقم المعرف:
      edsoai.on1360594364
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