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Dysfunction of cortical GABAergic neurons leads to sensory hyper-reactivity in a Shank3 mouse model of ASD

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اقرأ أكثر حفظ في قائمتي
  • المصدر:
    PMC
  • نوع التسجيلة:
    Electronic Resource
  • الدخول الالكتروني :
    https://hdl.handle.net/1721.1/130404.2
    http://dx.doi.org/10.1038/S41593-020-0598-6
    Nature Neuroscience
  • معلومة اضافية
    • Publisher Information:
      Springer Science and Business Media LLC 2022-03-14T18:14:56Z 2021-04-07T19:13:55Z 2022-03-14T18:14:56Z 2020-03 2018-08 2021-04-06T18:47:30Z
    • Added Details:
      McGovern Institute for Brain Research at MIT
      Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
      Chen, Qian
      Deister, Christopher A.
      Gao, Xian
      Guo, Baolin
      Lynn-Jones, Taylor
      Chen, Naiyan
      Wells, Michael F.
      Liu, Runpeng
      Goard, Michael J.
      Dimidschstein, Jordane
      Feng, Shijing
      Shi, Yiwu
      Liao, Weiping
      Lu, Zhonghua
      Fishell, Gord
      Moore, Christopher I.
      Feng, Guoping
    • نبذة مختصرة :
      Hyper-reactivity to sensory input is a common and debilitating symptom in individuals with autism spectrum disorders (ASD), but the neural basis underlying sensory abnormality is not completely understood. Here we examined the neural representations of sensory perception in the neocortex of a Shank3B−/− mouse model of ASD. Male and female Shank3B−/− mice were more sensitive to relatively weak tactile stimulation in a vibrissa motion detection task. In vivo population calcium imaging in vibrissa primary somatosensory cortex (vS1) revealed increased spontaneous and stimulus-evoked firing in pyramidal neurons but reduced activity in interneurons. Preferential deletion of Shank3 in vS1 inhibitory interneurons led to pyramidal neuron hyperactivity and increased stimulus sensitivity in the vibrissa motion detection task. These findings provide evidence that cortical GABAergic interneuron dysfunction plays a key role in sensory hyper-reactivity in a Shank3 mouse model of ASD and identify a potential cellular target for exploring therapeutic interventions.
      National Institutes of Health (Grant R01MH097104)
      NIMH (Grants P50MH094271, F32MH100749 and R01NS045130)
    • الموضوع:
      Article; http://purl.org/eprint/type/JournalArticle
    • Note:
      application/octet-stream
      English
    • Other Numbers:
      MYG oai:dspace.mit.edu:1721.1/130404.2
      1097-6256
      1546-1726
      Chen, Qian et al. "Dysfunction of cortical GABAergic neurons leads to sensory hyper-reactivity in a Shank3 mouse model of ASD." Nature Neuroscience 23, 4 (March 2020): 520–532 © 2020 The Author(s)
      1342476101
    • Contributing Source:
      MASSACHUSETTS INST OF TECHNOL LIBRS
      From OAIster®, provided by the OCLC Cooperative.
    • الرقم المعرف:
      edsoai.on1342476101
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