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Indocyanine Green Retention Test as a Predictor of Postoperative Complications in Patients with Hepatitis B Virus-Related Hepatocellular Carcinoma

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اقرأ أكثر حفظ في قائمتي
  • المؤلفون: Mai,Rong-Yun; Bai,Tao; Luo,Xiao-Ling; Wu,Guo-Bin
  • نوع التسجيلة:
    Electronic Resource
  • الدخول الالكتروني :
    https://www.dovepress.com/indocyanine-green-retention-test-as-a-predictor-of-postoperative-compl-peer-reviewed-fulltext-article-TCRM
    info:eu-repo/semantics/altIdentifier/doi/10.2147/TCRM.S363849
  • معلومة اضافية
    • Publisher Information:
      Dove Press 2022-08-02
    • نبذة مختصرة :
      Rong-Yun Mai,1,2 Tao Bai,1 Xiao-Ling Luo,2 Guo-Bin Wu1 1Department of Hepatobiliary & Pancreatic Surgery, Guangxi Medical University Cancer Hospital, Nanning, 530021, People’s Republic of China; 2Department of Experimental Research, Guangxi Medical University Cancer Hospital, Nanning, 530021, People’s Republic of ChinaCorrespondence: Guo-Bin Wu; Xiao-Ling Luo, Email wuguobin@gxmu.edu.cn; luoxiaoling67@126.comBackground: Accurate preoperative estimation of liver function reserve is the key to the safety of hepatectomy. Recently, indocyanine green retention test at 15 minutes (ICG-R15) has been widely used to estimate hepatic function reserve in different liver diseases. The purpose of this research was to investigate the clinical value of ICG-R15 in predicting postoperative major complications and severe posthepatectomy liver failure (PHLF) in patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) subjected to hepatectomy.Methods: A total of 354 HBV-associated HCC patients who underwent hepatectomy were enrolled. The Child–Pugh, model for end-stage liver disease (MELD), albumin–bilirubin (ALBI) and ICG-R15 for assessing postoperative complications risk were compared using receiver operating characteristic (ROC) curve and decision curve analysis (DCA).Results: Postoperative major complications developed in 32 patients (9.1%) and severe PHLF developed in 57 (16.1%) patients. Multivariate analyses revealed that ICG-R15 were independent factors for predicting postoperative major complications and severe PHLF. ROC curve analyses and DCA plots showed that the predictive abilities of ICG-R15 for postoperative major complications and severe PHLF risk was significantly greater than Child–Pugh, MELD, and ALBI scores. Similar results were obtained by stratifying different background subgroups. Then, patients were divided into three different risk cohorts, emphasizing the significantly discrepancy between the incidence of postoperative major c
    • الموضوع:
      Therapeutics and Clinical Risk Management; Original Research; info:eu-repo/semantics/article
    • Note:
      text/html
      English
    • Other Numbers:
      NZDMP oai:dovepress.com/77006
      1342153883
    • Contributing Source:
      DOVE MEDL PRESS LTD
      From OAIster®, provided by the OCLC Cooperative.
    • الرقم المعرف:
      edsoai.on1342153883
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