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Determinants of Restoration of CD4 and CD8 Cell Counts and Their Ratio in HIV-1-Positive Individuals With Sustained Virological Suppression on Antiretroviral Therapy

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  • المصدر:
    Antiretroviral Therapy Cohort Collaboration (ART-CC) 2019 , ' Determinants of Restoration of CD4 and CD8 Cell Counts and Their Ratio in HIV-1-Positive Individuals With Sustained Virological Suppression on Antiretroviral Therapy ' , Journal of acquired immune deficiency syndromes (1999) , vol. 80 , no. 3 , pp. 292-300 .
  • نوع التسجيلة:
    Electronic Resource
  • الدخول الالكتروني :
    https://curis.ku.dk/portal/da/publications/determinants-of-restoration-of-cd4-and-cd8-cell-counts-and-their-ratio-in-hiv1positive-individuals-with-sustained-virological-suppression-on-antiretroviral-therapy(9e3eb005-8aba-4407-a53f-45ee55dcf56f).html
    https://doi.org/10.1097/QAI.0000000000001913
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392208/pdf/qai-80-292.pdf
  • معلومة اضافية
    • Publisher Information:
      2019-03-01
    • نبذة مختصرة :
      BACKGROUND: An increasing number of HIV-positive individuals now start antiretroviral therapy (ART) with high CD4 cell counts. We investigated whether this makes restoration of CD4 and CD8 cell counts and the CD4:CD8 ratio during virologically suppressive ART to median levels seen in HIV-uninfected individuals more likely and whether restoration depends on gender, age, and other individual characteristics.METHODS: We determined median and quartile reference values for CD4 and CD8 cell counts and their ratio using cross-sectional data from 2309 HIV-negative individuals. We used longitudinal measurements of 60,997 HIV-positive individuals from the Antiretroviral Therapy Cohort Collaboration in linear mixed-effects models.RESULTS: When baseline CD4 cell counts were higher, higher long-term CD4 cell counts and CD4:CD8 ratios were reached. Highest long-term CD4 cell counts were observed in middle-aged individuals. During the first 2 years, median CD8 cell counts converged toward median reference values. However, changes were small thereafter and long-term CD8 cell count levels were higher than median reference values. Median 8-year CD8 cell counts were higher when ART was started with <250 CD4 cells/mm. Median CD4:CD8 trajectories did not reach median reference values, even when ART was started at 500 cells/mm.DISCUSSION: Starting ART with a CD4 cell count of ≥500 cells/mm makes reaching median reference CD4 cell counts more likely. However, median CD4:CD8 ratio trajectories remained below the median levels of HIV-negative individuals because of persisting high CD8 cell counts. To what extent these subnormal immunological responses affect specific clinical endpoints requires further investigation.
    • الموضوع:
      Adolescent; Adult; Anti-HIV Agents/therapeutic use; CD4 Lymphocyte Count; CD4-CD8 Ratio; CD8-Positive T-Lymphocytes; Cross-Sectional Studies; Female; HIV Infections/drug therapy; HIV-1; Humans; Longitudinal Studies; Lymphocyte Count; Male; Middle Aged; Viral Load/drug effects; Young Adult; article
    • Availability:
      Open access content. Open access content
      info:eu-repo/semantics/openAccess
    • Note:
      English
    • Other Numbers:
      DAV oai:pure.atira.dk:publications/9e3eb005-8aba-4407-a53f-45ee55dcf56f
      1322737953
    • Contributing Source:
      UNIV OF COPENHAGEN
      From OAIster®, provided by the OCLC Cooperative.
    • الرقم المعرف:
      edsoai.on1322737953
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