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Long Non-Coding RNAs Guide the Fine-Tuning of Gene Regulation in B-Cell Development and Malignancy

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اقرأ أكثر حفظ في قائمتي
  • المؤلفون: Dahl, Mette; Kristensen, Lasse Sommer; Grønbæk, Kirsten
  • المصدر:
    Dahl , M , Kristensen , L S & Grønbæk , K 2018 , ' Long Non-Coding RNAs Guide the Fine-Tuning of Gene Regulation in B-Cell Development and Malignancy ' , International Journal of Molecular Sciences , vol. 19 , no. 9 , 2475 .
  • نوع التسجيلة:
    Electronic Resource
  • الدخول الالكتروني :
    https://researchprofiles.ku.dk/da/publications/long-noncoding-rnas-guide-the-finetuning-of-gene-regulation-in-bcell-development-and-malignancy(2ceeceb4-dc3e-4b96-a3b0-00f83970d8d8).html
    https://doi.org/10.3390/ijms19092475
    https://curis.ku.dk/ws/files/215042204/ijms_19_02475.pdf
  • معلومة اضافية
    • Publisher Information:
      2018
    • نبذة مختصرة :
      With the introduction of next generation sequencing methods, such as RNA sequencing, it has become apparent that alterations in the non-coding regions of our genome are important in the development of cancer. Particularly interesting is the class of long non-coding RNAs (lncRNAs), including the recently described subclass of circular RNAs (circRNAs), which display tissue- and cell-type specific expression patterns and exert diverse regulatory functions in the cells. B-cells undergo complex and tightly regulated processes in order to develop from antigen naïve cells residing in the bone marrow to the highly diverse and competent effector cells circulating in peripheral blood. These processes include V(D)J recombination, rapid proliferation, somatic hypermutation and clonal selection, posing a risk of malignant transformation at each step. The aim of this review is to provide insight into how lncRNAs including circRNAs, participate in normal B-cell differentiation, and how deregulation of these molecules is involved in the development of B-cell malignancies. We describe the prognostic value and functional significance of specific deregulated lncRNAs in diseases such as acute lymphoblastic leukemia, chronic lymphocytic leukemia, mantle cell lymphoma, diffuse large B-cell lymphoma, follicular lymphoma, Burkitt lymphoma and multiple myeloma, and we provide an overview of the current knowledge on the role of circRNAs in these diseases.
    • الموضوع:
      B-Lymphocytes/immunology; Burkitt Lymphoma/genetics; Cell Differentiation; Cell Transformation, Neoplastic/genetics; Gene Expression Regulation, Neoplastic; Humans; Leukemia, Lymphocytic, Chronic, B-Cell/genetics; Lymphoma, Follicular/genetics; Lymphoma, Large B-Cell, Diffuse/genetics; Lymphoma, Mantle-Cell/genetics; Multiple Myeloma/genetics; Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics; RNA/genetics; RNA, Long Noncoding/genetics; Signal Transduction; article
    • Availability:
      Open access content. Open access content
      info:eu-repo/semantics/openAccess
    • Note:
      application/pdf
      English
    • Other Numbers:
      DAV oai:pure.atira.dk:publications/2ceeceb4-dc3e-4b96-a3b0-00f83970d8d8
      1322723518
    • Contributing Source:
      UNIV OF COPENHAGEN
      From OAIster®, provided by the OCLC Cooperative.
    • الرقم المعرف:
      edsoai.on1322723518
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