The Monash Autism-ADHD genetics and neurodevelopment (MAGNET) project design and methodologies: a dimensional approach to understanding neurobiological and genetic aetiology.

BioMed Central Ltd United Kingdom 2021-08-05

Background: ASD and ADHD are prevalent neurodevelopmental disorders that frequently co-occur and have strong evidence for a degree of shared genetic aetiology. Behavioural and neurocognitive heterogeneity in ASD and ADHD has hampered attempts to map the underlying genetics and neurobiology, predict intervention response, and improve diagnostic accuracy. Moving away from categorical conceptualisations of psychopathology to a dimensional approach is anticipated to facilitate discovery of data-driven clusters and enhance our understanding of the neurobiological and genetic aetiology of these conditions. The Monash Autism-ADHD genetics and neurodevelopment (MAGNET) project is one of the first large-scale, family-based studies to take a truly transdiagnostic approach to ASD and ADHD. Using a comprehensive phenotyping protocol capturing dimensional traits central to ASD and ADHD, the MAGNET project aims to identify data-driven clusters across ADHD-ASD spectra using deep phenotyping of symptoms and behaviours; investigate the degree of familiality for different dimensional ASD-ADHD phenotypes and clusters; and map the neurocognitive, brain imaging, and genetic correlates of these data-driven symptom-based clusters. Method(s): The MAGNET project will recruit 1,200 families with children who are either typically developing, or who display elevated ASD, ADHD, or ASD-ADHD traits, in addition to affected and unaffected biological siblings of probands, and parents. All children will be comprehensively phenotyped for behavioural symptoms, comorbidities, neurocognitive and neuroimaging traits and genetics. Conclusion(s): The MAGNET project will be the first large-scale family study to take a transdiagnostic approach to ASD-ADHD, utilising deep phenotyping across behavioural, neurocognitive, brain imaging and genetic measures.Copyright © 2021, The Author(s).

AUSHL oai:repository.monashhealth.org:1/42821
Molecular Autism. 12 (1) (no pagination), 2021. Article Number: 55. Date of Publication: December 2021.
https://repository.monashhealth.org/monashhealthjspui/handle/1/42821
(Knott, Johnson, Tiego, Mellahn, Finlay, Kallady, Kouspos, Mohanakumar Sindhu, Hawi, Arnatkeviciute, Chau, Maron, Mercieca, Furley, Fornito, Bellgrove) Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, 18 Innovation Walk, Melbourne, VIC 3800, Australia
(Harris, Williams, Ure) Department of Paediatrics, Monash University, Melbourne, VIC 3800, Australia
(Harris, Williams) Department of Developmental Paediatrics, Monash Children's Hospital, 246 Clayton Rd, Clayton, VIC 3168, Australia
(Williams, Ure) Murdoch Children's Research Institute, Royal Children's Hospital, 50 Flemington Rd, Parkville, VIC 3052, Australia
(Williams, Coghill) Department of Paediatrics, Faculty of Medicine, Dentistry and Health Sciences, Royal Children's Hospital, 50 Flemington Road, Parkville, VIC 3052, Australia
(Ure, Coghill) Department of Mental Health, Royal Children's Hospital, 50 Flemington Rd, Parkville, VIC 3052, Australia
(Ure, Coghill) Neurodevelopment and Disability Research, Murdoch Children's Research Institute, Royal Children's Hospital, 50 Flemington Rd, Parkville, VIC 3052, Australia
(Gray) Centre for Educational Development, Appraisal, and Research, University of Warwick, Coventry CV4 7AL, United Kingdom
(Gray) Department of Psychiatry, School of Clinical Sciences, Monash University, 246 Clayton Rd, Melbourne, VIC 3168, Australia
(Nicholson, Phung) Faculty of Information and Technology, Monash University, Melbourne, VIC 3800, Australia
(Loth, Murphy) Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology and Neuroscience, King's College London, De Crespigny Park, Denmark Hill, London SE5 8AF, United Kingdom
(Loth, Murphy) Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, De Crespigny Park, Denmark Hill, London SE5 8AF, United Kingdom
(Mason) Centre for Brain and Cognitive Development, Birkbeck, University of London, Henry Welcome Building, Malet Street, London WC1E 7HX, United Kingdom
(Buitelaar) Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Kapittelweg 29, Nijmegen 6525 EN, Netherlands
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