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Cardiac regenerative capacity: an evolutionary afterthought?

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اقرأ أكثر حفظ في قائمتي
  • المؤلفون: Nguyen, Phong D; de Bakker, Dennis E M; Bakkers, Jeroen
  • المصدر:
    Cellular and Molecular Life Sciences vol.78 (2021) nr.12 p.5107-5122 [ISSN 1420-682X]
  • نوع التسجيلة:
    Electronic Resource
  • الدخول الالكتروني :
    https://pure.knaw.nl/portal/en/publications/c5e90f99-a104-4a30-a47f-35027e00414f
  • معلومة اضافية
    • Publisher Information:
      2021
    • نبذة مختصرة :
      Cardiac regeneration is the outcome of the highly regulated interplay of multiple processes, including the inflammatory response, cardiomyocyte dedifferentiation and proliferation, neovascularization and extracellular matrix turnover. Species-specific traits affect these injury-induced processes, resulting in a wide variety of cardiac regenerative potential between species. Indeed, while mammals are generally considered poor regenerators, certain amphibian and fish species like the zebrafish display robust regenerative capacity post heart injury. The species-specific traits underlying these differential injury responses are poorly understood. In this review, we will compare the injury induced processes of the mammalian and zebrafish heart, describing where these processes overlap and diverge. Additionally, by examining multiple species across the animal kingdom, we will highlight particular traits that either positively or negatively affect heart regeneration. Last, we will discuss the possibility of overcoming regeneration-limiting traits to induce heart regeneration in mammals.
    • الموضوع:
      Animals; Biological Evolution; Heart/embryology; Heart Diseases/therapy; Humans; Myocytes, Cardiac/cytology; Regeneration; Boek/film/artikelrecensie; Book/Film/Article review
    • Availability:
      Open access content. Open access content
      info:eu-repo/semantics/openAccess
    • Note:
      DOI: 10.1007/s00018-021-03831-9
      Cellular and Molecular Life Sciences vol.78 (2021) nr.12 p.5107-5122 [ISSN 1420-682X]
      English
    • Other Numbers:
      NLKNA oai:pure.knaw.nl:publications/c5e90f99-a104-4a30-a47f-35027e00414f
      https://pure.knaw.nl/portal/en/publications/c5e90f99-a104-4a30-a47f-35027e00414f
      1295311691
    • Contributing Source:
      KON NED AKADEMIE VAN WETENSCHAPPEN
      From OAIster®, provided by the OCLC Cooperative.
    • الرقم المعرف:
      edsoai.on1295311691
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