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Mismatch negativity impairment is associated with deficits in identifying real-world environmental sounds in schizophrenia.

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  • معلومة اضافية
    • Publisher Information:
      eScholarship, University of California 2018-01-01
    • نبذة مختصرة :
      BackgroundPatients with schizophrenia (SZ) have impairments in processing auditory information that have been linked to deficits in cognitive and psychosocial functioning. Dysfunction in auditory sensory processing in SZ has been indexed by mismatch negativity (MMN), an event-related potential evoked by a rare, deviant stimulus embedded within a sequence of identical standard stimuli. Although MMN deficits in SZ have been studied extensively, relatively little is known about how these deficits relate to accurately identifying real-world, ecologically-salient sounds.MethodsMMN was assessed in SZ patients (n=21) and non-psychiatric comparison subjects (NCS; n=16). Participants were also assessed in their ability to identify common environmental sounds using a subset of 80 sound clips from the International Affective Digitized Sounds 2nd Ed collection.ResultsSZ patients made significantly more errors in environmental sound identification (p<0.001, d=0.86) and showed significantly reduced MMN amplitude deficits in MMN compared to NCS (p<0.01, d=0.97). In SZ patients, MMN deficits were associated with significantly greater environmental sound identification errors (r=0.61, p<0.01).ConclusionsImpairments in early auditory information processing in schizophrenia account for significant proportions of variance in the ability to identify real-world, functionally relevant environmental sounds. This study supports the view that interventions targeting deficits in low-level auditory sensory processing may also impact more complex cognitive brain processes relevant to psychosocial disability.
    • الموضوع:
      Humans; Electroencephalography; Acoustic Stimulation; Emotions; Arousal; Schizophrenia; Psychiatric Status Rating Scales; Schizophrenic Psychology; Environment; Contingent Negative Variation; Evoked Potentials; Auditory; Adult; Middle Aged; Female; Male; Statistics as Topic; Psychiatry; Medical and Health Sciences; Psychology and Cognitive Sciences; publication
    • Availability:
      Open access content. Open access content
      public
    • Note:
      application/pdf
    • Other Numbers:
      CDLER oai:escholarship.org:ark:/13030/qt3xn591sq
      qt3xn591sq
      https://escholarship.org/uc/item/3xn591sq
      https://escholarship.org/
      1287355801
    • Contributing Source:
      UC MASS DIGITIZATION
      From OAIster®, provided by the OCLC Cooperative.
    • الرقم المعرف:
      edsoai.on1287355801
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