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Isoaspartylation appears to trigger small cell lung cancer-associated autoimmunity against neuronal protein ELAVL4.

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  • معلومة اضافية
    • Publisher Information:
      eScholarship, University of California 2016-10-01
    • نبذة مختصرة :
      Autoantibodies against SCLC-associated neuronal antigen ELAVL4 (HuD) have been linked to smaller tumors and improved survival, but the antigenic epitope and mechanism of autoimmunity have never been solved. We report that recombinant human ELAVL4 protein incubated under physiological conditions acquires isoaspartylation, a type of immunogenic protein damage. Specifically, the N-terminal region of ELAVL4, previously implicated in SCLC-associated autoimmunity, undergoes isoaspartylation in vitro, is recognized by sera from anti-ELAVL4 positive SCLC patients and is highly immunogenic in subcutaneously injected mice and in vitro stimulated human lymphocytes. Our data suggest that isoaspartylated ELAVL4 is the trigger for the SCLC-associated anti-ELAVL4 autoimmune response.
    • الموضوع:
      Neurons; Animals; Mice; Knockout; Rabbits; Humans; Lung Neoplasms; Autoimmunity; Amino Acid Sequence; Adult; Aged; Middle Aged; Female; Male; Small Cell Lung Carcinoma; ELAV-Like Protein 4; Isoaspartylation; SCLC; Small cell lung cancer; Neurology & Neurosurgery; Immunology; Neurosciences; publication
    • Availability:
      Open access content. Open access content
      public
    • Note:
      application/pdf
    • Other Numbers:
      CDLER oai:escholarship.org:ark:/13030/qt43v5k0mg
      qt43v5k0mg
      https://escholarship.org/uc/item/43v5k0mg
      https://escholarship.org/
      1287309413
    • Contributing Source:
      UC MASS DIGITIZATION
      From OAIster®, provided by the OCLC Cooperative.
    • الرقم المعرف:
      edsoai.on1287309413
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