Protein kinase inhibitors for amyotrophic lateral sclerosis therapy

John Wiley & Sons 2020-08-01

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder that causes the progressive loss of motoneurons and, unfortunately, there is no effective treatment for this disease. Interconnecting multiple pathological mechanisms are involved in the neuropathology of this disease, including abnormal aggregation of proteins, neuroinflammation and dysregulation of the ubiquitin proteasome system. Such complex mechanisms, together with the lack of reliable animal models of the disease have hampered the development of drugs for this disease. Protein kinases, a key pharmacological target in several diseases, have been linked to ALS as they play a central role in the pathology of many diseases. Therefore several inhibitors are being currently trailed for clinical proof of concept in ALS patients. In this review, we examine the recent literature on protein kinase inhibitors currently in pharmaceutical development for this diseaseas future therapy for AS together with their involvement in the pathobiology of ALS.

ALS; CK-1d; Masitinib; Protein kinase inhibitors; Rapamycin; TDP-43; artículo

Open access content. Open access content
openAccess

English

CTK oai:digital.csic.es:10261/219477
Br J Pharmacol 178:1316-1335 (2021)
0007-1188
10.1111/bph.15221
1476-5381
1286554337

CSIC
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