Combining Organocatalyzed Aldolization and Reductive Amination: An Efficient Reaction Sequence for the Synthesis of Iminosugars

Wiley 2021

Ferjančić, Zorana
Saičić, Radomir

Over the past two decades, organocatalytic aldol reaction emerged as a powerful method for the enantioselective carbon–carbon bond formation, often offering more efficient, economical and environmentally friendly synthesis of chiral molecules. On the other hand, reductive amination is one of the most important reactions in synthesis of biologically active compounds and drug candidates. Coupling these two reactions results in a powerful combination that allows for a rapid, stereoselective access to substituted, highly functionalized five- and six-membered N-heterocycles. This minireview illustrates the applicability of this approach as the key feature in syntheses of various iminosugars – a class of polyhydroxylated alkaloids with a range of interesting biological activities and high pharmacological potential.

Aldol reaction; Asymmetric synthesis; Iminosugars; Organocatalysis; Reductive amination; article

European Journal of Organic Chemistry

RSPST oai:cherry.chem.bg.ac.rs:123456789/4576
1434-193X
https://onlinelibrary.wiley.com/doi/abs/10.1002/ejoc.202100398
https://cherry.chem.bg.ac.rs/handle/123456789/4576
000664610800012
10.1002/ejoc.202100398
2-s2.0-85108284643
1269080239

UIVERSITY OF BELGRADE
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