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In vitro antioxidant, antihyperglycemic, anti-inflammatory, and antimicrobial activity of Satureja kitaibelii Wierzb. ex Heuff. subcritical water extract

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اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • Publisher Information:
      Elsevier 2021
    • نبذة مختصرة :
      As the main goal of this study was the verification of Satureja kitaibelii Wierzb. ex Heuff. in form of the crude extract obtained by subcritical water extraction (SWE) technique in terms of polyphenolic composition, in vitro antioxidant capacity, antihyperglycemic, and anti-inflammatory activities as well as an antimicrobial effect against 10 microorganisms. HPLC analysis showed the presence of ten compounds in a total concentration of 89.33 mg/g of the SWE extract, and demonstrated that subcritical water polarity was the most selective for extracting syringic and caffeic acid, as well as epicatechin (37.88 18.06, and 10.04 mg/g, respectively), while flavonoids like rutin, luteolin, and apigenin were present in low concentration (<2 mg/g). Results of antioxidant activity assays revealed that superoxide anion and ABTS•+ radical models expressed the highest scavenging abilities (437.35 and 412.09 μmol TE/g, respectively), followed by lipid radicals (69.61 μmol TE/g), and DPPH• (32.28 μmol TE/g), while in the case of ferric ion reducing ability was noted a high value (118.19 μmol TE/g). S. kitaibelii SWE was less efficient in the antihyperglycemic assay (AhgA = 30.72 %), but the high antiinflammatory activity of S. kitaibelii SWE was observed (30.35 %). The antimicrobial activity was demonstrated against Bacillus cereus, Staphylococcus aureus, Enterococcus faecalis, Listeria monocytogenes as well as Saccharomyces cerevisiae, Candida albicans, and Aspergillus brasiliensis through antimicrobial screening, minimal inhibitory concentration, and pharmacodynamics study.
    • الموضوع:
      Subcritical water extraction; Satureja kitaibelii; Phytochemical composition; Antioxidant capacity; Antimicrobial activity; article
    • Note:
      Industrial Crops and Products
      English
    • Other Numbers:
      RSPST oai:fiver.ifvcns.rs:123456789/2196
      0926-6690
      10.1016/j.indcrop.2021.113672
      1262369625
    • Contributing Source:
      UIVERSITY OF BELGRADE
      From OAIster®, provided by the OCLC Cooperative.
    • الرقم المعرف:
      edsoai.on1262369625
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