Single-nucleotide polymorphism alleles in the insulin receptor gene are associated with typical migraine

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المؤلفون: McCarthy, Linda C.; Hosford, David A.; Riley, John H.; Bird, Michael I.; White, Nicola J.; Hewett, Duncan R.; Peroutka, Stephen J.; Griffiths, Lyn R.; Boyd, Pete R.; Lea, Rod A.; Bhatti, Shahid M.; Hosking, Louise K.; Hood, Chris M.; Jones, Keith W.; Handley, Abigail R.; Rallan, Raj; Lewis, Karen F.; Yeo, Astrid J.M.; Williams, Pauline M.; Priest, Richard C.; Khan, Parveen; Donnelly, Christine; Lumsden, Sheena M.; O'Sullivan, Jennifer; See, Chee Gee; Smart, Devi H.; Shaw-Hawkins, Sue; Patel, Jaymini; Langrish, Tony C.; Feniuk, Wasyl; Knowles, Richard G.; Thomas, Malcolm; Libri, Vincenzo; Montgomery, Doug S.; Manasco, Penny K.; Xu, Chun Fang; Dykes, Colin; Humphrey, Patrick P.A.; Roses, Allen D.; Purvis, Ian J.
المصدر:
Genomics
نوع التسجيلة:
Electronic Resource
الدخول الالكتروني :
doi:10.1006/geno.2001.6647
McCarthy, Linda C., Hosford, David A., Riley, John H., Bird, Michael I., White, Nicola J., Hewett, Duncan R., Peroutka, Stephen J., Griffiths, Lyn R., Boyd, Pete R., Lea, Rod A., Bhatti, Shahid M., Hosking, Louise K., Hood, Chris M., Jones, Keith W., Handley, Abigail R., Rallan, Raj, Lewis, Karen F., Yeo, Astrid J.M., Williams, Pauline M., Priest, Richard C., Khan, Parveen, Donnelly, Christine, Lumsden, Sheena M., O'Sullivan, Jennifer, See, Chee Gee, Smart, Devi H., Shaw-Hawkins, Sue, Patel, Jaymini, Langrish, Tony C., Feniuk, Wasyl, Knowles, Richard G., Thomas, Malcolm, Libri, Vincenzo, Montgomery, Doug S., Manasco, Penny K., Xu, Chun Fang, Dykes, Colin, Humphrey, Patrick P.A., Roses, Allen D., & Purvis, Ian J. (2001) Single-nucleotide polymorphism alleles in the insulin receptor gene are associated with typical migraine. Genomics, 78(3), pp. 135-149.

معلومة اضافية
- Publisher Information:
  Academic Press 2001-09-15
- نبذة مختصرة :
  We have identified a migraine locus on chromosome 19p13.3/2 using linkage and association analysis. We isolated 48 single-nucleotide polymorphisms within the locus, of which we genotyped 24 in a Caucasian population comprising 827 unrelated cases and 765 controls. Five single-nucleotide polymorphisms within the insulin receptor gene showed significant association with migraine. This association was independently replicated in a case-control population collected separately. We used experiments with insulin receptor RNA and protein to investigate functionality for the migraine-associated single-nucleotide polymorphisms. We suggest possible functions for the insulin receptor in migraine pathogenesis.
- الموضوع:
  Association mapping; Complex disease; Disease susceptibility; Insulin receptor; Linkage disequilibrium mapping; Migraine; Migraine gene; SNPs; Contribution to Journal
- Availability:
  Open access content. Open access content
  Consult author(s) regarding copyright matters
  This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au
- Other Numbers:
  ATUTQ oai:eprints.qut.edu.au:203236
  Faculty of Education; Institute of Health and Biomedical Innovation; School of Teacher Education & Leadership
  1255559654
- Contributing Source:
  QUEENSLAND UNIV OF TECH
  From OAIster®, provided by the OCLC Cooperative.
- الرقم المعرف:
  edsoai.on1255559654

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Single-nucleotide polymorphism alleles in the insulin receptor gene are associated with typical migraine

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