Long-term evaluation of quality of life and gastrointestinal well-being after segmental colo-rectal resection for deep infiltrating endometriosis (ENDO-RESECT QoL)

Springer 2020

Turco, L. C.
Scaldaferri, Franco
Chiantera, V.
Cianci, Stefano
Ercoli, A.
Fagotti, Anna
Fanfani, Francesco
Ferrandina, Maria Gabriella
Nicolotti, N.
Tamburrano, A.
Vargiu, V.
Scambia, Giovanni
Cosentino, Francesco
Scaldaferri F. (ORCID:0000-0001-8334-7541)
Cianci S.
Fagotti A. (ORCID:0000-0001-5579-335X)
Fanfani F. (ORCID:0000-0003-1991-7284)
Ferrandina G. (ORCID:0000-0003-4672-4197)
Scambia G. (ORCID:0000-0003-2758-1063)
Cosentino F.

Purposes: The primary objective is to assess the long-term quality of life (QoL) and gastrointestinal well-being in patients with endometriosis (DIE) who underwent segmental resection (SR), through specific questionnaires focused on endometriosis and specific gastrointestinal evaluation. The secondary objectives are represented by the evaluation of peri-operative and post-operative outcomes of the procedure. Methods: This observational cohort study ENDO-RESECT (ClinicalTrials.gov ID: NCT03824054) reports all clinical data about women who underwent SR for DIE between October 2005 and November 2017. In the part of the study dedicated to the QoL assessment, the questionnaires adopted were the Endometriosis Health Profile (EHP30), the Psychological General Well-Being Index and the Hospital Anxiety and Depression Scale, the Gastrointestinal Well-being questionnaire and the Bristol Stool chart. Major post-surgical morbidity and obstetric outcomes were also collected. Results: 50 women (18% stage III and 82% stage IV rAFS) were considered for enrollment. EHP-30 interpretation demonstrated a significant improvement in all continuous variables, except for fertility concerns. The overall gastrointestinal QoL and most of the specific symptoms improved after surgery. Frequent bowel movements appeared in the 13% of the series not resulting in an impairment of general and gastrointestinal QoL. Constipation remained unchanged. Patients with depressive mood managed with laparoscopy, benefited the most from SR; moreover, patients with multinodular bowel localizations experienced a greater reduction in abdominal pain. Median FU after SR was 42.5 months (range 12–157 months). Only three (6%) cases of late major grade III complications were documented. The pregnancy rate was 50%. Conclusions: Improvement of general QoL and most of gastrointestinal symptoms was documented after SR.

Deep infiltrating endometriosis; Gastrointestinal symptoms; Intestinal endometriosis; Personalized medicine; Quality of life; Segmental colo-rectal resection; Adolescent; Adult; Cohort Studies; Colorectal Neoplasms; Endometriosis; Female; Gastrointestinal Diseases; Humans; Middle Aged; Postoperative Complications; Pregnancy; Quality of Life; Surveys and Questionnaires; Treatment Outcome; Young Adult; Settore MED/40 - GINECOLOGIA E OSTETRICIA; info:eu-repo/semantics/article

English

SYC oai:publicatt.unicatt.it:10807/167324
10.1007/s00404-019-05382-8
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85075386097
1242038809

UNIV CATTOLICA DEL SACRO CUORE
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