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Cholesterol uptake in the mouse aorta increases during Chlamydia pneumoniae infection

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  • معلومة اضافية
    • Publisher Information:
      Uppsala universitet, Infektionssjukdomar Swedish Univ Agr Sci, Dept Biomed Sci & Vet Publ Hlth, S-75007 Uppsala, Sweden. Natl Food Agcy, Risk Benefit Assessment Dept, S-75126 Uppsala, Sweden. OXFORD UNIV PRESS 2017
    • نبذة مختصرة :
      Chlamydia pneumoniae has been suggested as a stimulator of the atherosclerotic process. Mice fed a normal diet were infected intranasally with C. pneumoniae and given one intraperitoneal injection of C-14-cholesterol tracer per day for 12 days. Bacteria were demonstrated in the aorta in the early phase of infection and in lungs and liver throughout the study period of 20 days. C-14-cholesterol was not affected in the heart but increased in the blood, liver and aorta on day 4 when the infection was clinically most severe. Furthermore, on day 20 C-14-cholesterol tended to be increased in the aorta. Accordingly, copper-and zinc levels and expressions of the infection biomarkers Cxcl2 and Ifng increased in the liver on day 4 with a tendency of increased of copper, zinc and Ifng on day 20. In mice where bacteria could be cultivated from the lungs, expressions of cholesterol transporters Abca1 and Idol were both increased in the liver on day 4. The increased levels of C-14-cholesterol in blood and aorta together with increased Abca1 and Idol in the liver during C. pneumoniae infection in mice fed a normal diet suggest that this pathogen may have a role in the initiation of the atherosclerotic process.
    • الموضوع:
      Chlamydia pneumoniae; atherosclerosis; cholesterol; Idol; Abca1; Cxcl2; interferon gamma; mouse; copper; zinc; Infectious Medicine; Infektionsmedicin; Article in journal; info:eu-repo/semantics/article; text
    • الرقم المعرف:
      10.1093.femspd.ftx004
    • Availability:
      Open access content. Open access content
      info:eu-repo/semantics/restrictedAccess
    • Note:
      English
    • Other Numbers:
      UPE oai:DiVA.org:uu-320821
      0000-0003-2845-9190
      doi:10.1093/femspd/ftx004
      PMID 28158541
      ISI:000398086700008
      1235205533
    • Contributing Source:
      UPPSALA UNIV LIBR
      From OAIster®, provided by the OCLC Cooperative.
    • الرقم المعرف:
      edsoai.on1235205533
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