TGF-beta signaling from a three-dimensional perspective : insight into selection of partners

Ludwiginstitutet för cancerforskning 2002

Members of the transforming growth factor beta (TGF-beta) family, which include TGF-beta s, activins and bone morphogenetic proteins (BMPs), are potent regulators of cell proliferation, differentiation, migration and apoptosis. They act through binding to and activating serine/threonine kinase receptors on the cell surface and triggering intracellular signaling pathways in which Smad proteins have essential roles. Here, we discuss recent structure-based studies of TGF-beta s and BMPs, their receptors, and of Smad proteins, which have unravelled insights into ligand specificity, receptor and Smad activation, as well as new features of Smads as phosphoserine-binding entities.

Animals; Bone Morphogenetic Proteins/chemistry/physiology; Crystallography; X-Ray; DNA-Binding Proteins/chemistry/physiology; Humans; Models; Molecular; Protein Conformation; Signal Transduction; Smad Proteins; Trans-Activators/chemistry/physiology; Transforming Growth Factor beta/*chemistry/physiology; Medical and Health Sciences; Medicin och hälsovetenskap; Article, review/survey; info:eu-repo/semantics/article; text

10.1016.S0962-8924(02)02300-0

Open access content. Open access content
info:eu-repo/semantics/restrictedAccess

English

UPE oai:DiVA.org:uu-10419
doi:10.1016/S0962-8924(02)02300-0
PMID 12185845
1235182967

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