Local release of human neutrophil lipocalin (HNL), IL-8, and TNF-alpha is decreased as response to topical prednisolone treatment in distal ulcerative colitis and proctitis

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المؤلفون: Sangfelt, Per; Carlson, Marie; Thörn, Magnus; Xu, Shengyuan; Lööf, Lars; Raab, Yngve
نوع التسجيلة:
Electronic Resource
الدخول الالكتروني :
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-74311
Digestive Diseases and Sciences, 0163-2116, 2002, 47:9, s. 2064-2069

معلومة اضافية
- Publisher Information:
  Institutionen för medicinska vetenskaper Institutionen för kirurgiska vetenskaper Centrum för klinisk forskning, Västerås 2002
- نبذة مختصرة :
  The local release of human neutrophil lipocalin, considered to be highly specific for neutrophil granulocyte activation, and interleukin-8 and tumor necrosis factor-a were studied in 11 patients with distal ulcerative colitis and proctitis before and during treatment with steroid enemas. A rectal perfusion technique for sampling and specific immunoassays for analysis were used. In responders (N = 8) the concentrations of all proteins decreased during the study. There was a close correlation between human neutrophil lipocalin concentrations and treatment response. Tumor necrosis factor-a showed an initial decline in concentrations irrespective of treatment outcome and preceded the decline of human neutrophil lipocalin and interleukin-8. We conclude that decreased neutrophil degranulation is correlated with treatment outcome. Furthermore, an important role of tumor necrosis factor-a in the process of stimulating neutrophil activation and degranulation in ulcerative colitis is suggested.
- الموضوع:
  Acute-Phase Proteins; Anti-Inflammatory Agents/administration & dosage/*therapeutic use; Carrier Proteins/*metabolism; Colitis; Ulcerative/*drug therapy/metabolism; Enema; Humans; Interleukin-8/*metabolism; Neutrophils/*metabolism; Oncogene Proteins; Prednisolone/administration & dosage/*therapeutic use; Proctitis/*drug therapy/metabolism; Research Support; Non-U.S. Gov't; Tumor Necrosis Factor-alpha/*metabolism; Medical and Health Sciences; Medicin och hälsovetenskap; Article in journal; info:eu-repo/semantics/article; text
- الرقم المعرف:
  10.1023.A:1019681030784
- Availability:
  Open access content. Open access content
  info:eu-repo/semantics/restrictedAccess
- Note:
  English
- Other Numbers:
  UPE oai:DiVA.org:uu-74311
  doi:10.1023/A:1019681030784
  PMID 12353856
  1235128572
- Contributing Source:
  UPPSALA UNIV LIBR
  From OAIster®, provided by the OCLC Cooperative.
- الرقم المعرف:
  edsoai.on1235128572

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Local release of human neutrophil lipocalin (HNL), IL-8, and TNF-alpha is decreased as response to topical prednisolone treatment in distal ulcerative colitis and proctitis

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