Carnosic acid-rich rosemary (Rosmarinus officinalis L.) leaf extract limits weight gain and improves cholesterol levels and glycaemia in mice on a high-fat diet

Cambridge University Press Hispana 2011

Rosemary (Rosmarinus officinalis L.) extracts (RE) are natural antioxidants that are used in food, food supplements and cosmetic applications; exert anti-inflammatory and anti-hyperglycaemic effects; and promote weight loss, which can be exploited to develop new preventive strategies against metabolic disorders. Therefore, the aim of the present study was to evaluate the preventive effects of rosemary leaf extract that was standardised to 20 % carnosic acid (RE) on weight gain, glucose levels and lipid homeostasis in mice that had begun a high-fat diet (HFD) as juveniles. The animals were given a low-fat diet, a HFD or a HFD that was supplemented with 500 mg RE/kg body weight per d (mpk). Physiological and biochemical parameters were monitored for 16 weeks. Body and epididymal fat weight in animals on the HFD that was supplemented with RE increased 69 and 79 % less than those in the HFD group. Treatment with RE was associated with increased faecal fat excretion but not with decreased food intake. The extract also reduced fasting glycaemia and plasma cholesterol levels. In addition, we evaluated the inhibitory effects of RE in vitro on pancreatic lipase and PPAR-¿ agonist activity; the in vitro findings correlated with our observations in the animal experiments. Thus, the present results suggest that RE that is rich in carnosic acid can be used as a preventive treatment against metabolic disorders, which merits further examination at physiological doses in randomised controlled trials. © Copyright © The Authors 2011.

Carnosic acid; Pancreatic lipase; PPAR-¿; Rosmarinus officinalis L.; Cholesterol; Fatty acid; Glucose; Insulin; Peroxisome proliferator activated receptor gamma; Rosiglitazone; Rosmarinus officinalis extract; Triacylglycerol; Triacylglycerol lipase; Animal cell; Animal experiment; Article; Body weight; Caloric intake; Cholesterol blood level; Chronic drug administration; Controlled study; Epididymis fat; Epididymis fat weight; Experimental model; Fatty acid blood level; Fecal fat excretion; Feces analysis; Food intake; Glucose blood level; In vitro study; Insulin blood level; Juvenile animal; Lipid diet; Liver weight; Low fat diet; Male; Mouse; Nonhuman; Plant leaf; Triacylglycerol blood level; Weight gain; Animals; Antioxidants; Blood Glucose; Diet, High-Fat; Diterpenes, Abietane; Eating; Metabolic Diseases; Mice; Mice, Inbred C3H; Organ Size; Phytotherapy; Plant Extracts; Plant Leaves; Rosmarinus; Animalia; Mus; Rosmarinus officinalis; TECNOLOGIA DE ALIMENTOS; info:eu-repo/semantics/article

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UPV oai:riunet.upv.es:10251/27906
urn:issn:0007-1145
info:doi:10.1017/S0007114511001620
https://riunet.upv.es/bitstream/10251/27906/5/Ibarra et al. Rosemary limits weight gain. Br J Nutr 2011.pdf.jpg
1138422943

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