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Socioeconomic influences on late-life health and mortality : exploring genetic and environmental interplay

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اقرأ أكثر حفظ في قائمتي
  • المؤلفون: Ericsson, Malin
  • نوع التسجيلة:
    Electronic Resource
  • الدخول الالكتروني :
    http://hdl.handle.net/10616/46815
    I. Ericsson, M., Lundholm, C., Fors, S., Dahl Aslan, A. K., Zavala, C., Reynolds, C. A., & Pedersen, N. L. (2017). Childhood social class and cognitive aging in the Swedish Adoption/Twin Study of Aging. Proceedings of the National Academy of Sciences. 114(27), 7001-7006. ::doi::10.1073/pnas.1620603114 ::pmid::28630290 ::isi::000404576100053
    II. Ericsson, M., Kuja-Halkola, R., Dahl Aslan, A. K., Fors, S., Zavala, C., Reynolds, C. A., & Pedersen, N. L. Socioeconomic status as a moderator of late-life cognitive abilities: Exploring childhood and attained socioeconomic circumstances. [Manuscript]
    III. Ericsson, M., Pedersen, N. L., Johansson, A. L. V., Fors, S., & Dahl Aslan, A. K. (2019). Life-course socioeconomic differences and social mobility in preventable and non-preventable mortality: a study of Swedish twins. Int J Epidemiol. Mar 30, pii: dyz042. ::doi::10.1093/ije/dyz042 ::pmid::30929008
    IV. Ericsson, M., Pedersen, N. L., Fors, S., Kuja-Halkola, R., Mosing, M., Li, X., Jylhävä, J., and Dahl Aslan, A. K. Frailty and mortality: Investigating sex differences and socioeconomic influences using same-sex and opposite-sex Swedish twins. [Manuscript]
  • معلومة اضافية
    • Publisher Information:
      Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics 2019-09-13
    • نبذة مختصرة :
      The objective of this thesis was to increase the understanding of socioeconomic differences in health and mortality in old age - in a genetically informative setting. Data from the Swedish Twin Registry (STR), different statistical methods, and family-based designs were applied to investigate socioeconomic circumstances over the life-course and how these affect cognitive function, frailty, and mortality in late life. In Study I, we studied the effect of rearing social class on late-life cognitive ability. An association between rearing social class and cognitive ability at age 65 was observed, but there was no effect on cognitive change. After controlling for familial influences, the association between rearing social class and late-life cognitive ability no longer remained and could instead be attributed to genetic influences. In Study II, we used a classical twin design to investigate if childhood and attained socioeconomic indicators moderates the effects of genes and environment on late-life cognitive abilities. Cognitive ability was measured via four cognitive tests and a general ability score. Estimates of intercepts from growth models centered at age 75 and two linear slopes (before and after age 75) were utilized in the moderation models. The results from the moderator models for the four socioeconomic indicators showed similar patterns for the intercept. For cognitive change, moderation differed depending on cognitive test and socioeconomic indicator. In Study III, we investigated mortality inequalities by comparing preventable and non-preventable mortality using a survival model. Familial confounding was analyzed using a co-twin control method. We observed a social gradient for mortality for the adult socioeconomic measures, which was stronger for preventable mortality than for non-preventable mortality. Adjustments for familial confounding did not change the observed associations between the attained socioeconomic indicators and mortality. However, the as
    • الموضوع:
      info:eu-repo/semantics/doctoralThesis
    • Note:
      English
    • Other Numbers:
      SEKIU oai:openarchive.ki.se:10616/46815
      978-91-7831-522-2
      1134578076
    • Contributing Source:
      KAROLINSKA INSTITUTET UNIV
      From OAIster®, provided by the OCLC Cooperative.
    • الرقم المعرف:
      edsoai.on1134578076
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