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Low microRNA-622 expression predicts poor prognosis and is associated with ZEB2 in glioma

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  • المؤلفون: Song,Qian; Pang,Honggang; Qi,Lei; Liang,Chen; Wang,Tuo; Wang,Wei; Li,Ruichun
  • نوع التسجيلة:
    Electronic Resource
  • الدخول الالكتروني :
    https://www.dovepress.com/low-microrna-622-expression-predicts-poor-prognosis-and-is-associated--peer-reviewed-fulltext-article-OTT
    info:eu-repo/semantics/altIdentifier/doi/10.2147/OTT.S218161
  • معلومة اضافية
    • Publisher Information:
      Dove Press 2019-09-10
    • نبذة مختصرة :
      Qian Song,1 Honggang Pang,2 Lei Qi,1 Chen Liang,1 Tuo Wang,1 Wei Wang,1 Ruichun Li1 1Department of Neurosurgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi 710061, People’s Republic of China; 2Department of Peripheral Vascular Disease, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi 710061, People’s Republic of ChinaCorrespondence: Ruichun LiDepartment of Neurosurgery, The First Affiliated Hospital of Xi’an Jiaotong University, No. 277 Yanta West Road, Xi’an, Shaanxi 710061, People’s Republic of ChinaEmail fourcycle@126.comBackground: MicroRNAs have been recently reported to play an important role in tumorigenesis and progression in several forms of tumors. Previous studies have shown that microRNA-622 (miR-622) was associated with glioma proliferation and invasion. However, the clinical significance of miR-622 in glioma has not been elucidated. The aim of our study was to investigate the clinical values of miR-622, as well as investigate the potential molecular mechanisms in glioma.Materials and methods: qRT-PCR and Western blot analysis were used to analyze the expression of miR-622 and ZEB2, respectively. Kaplan–Meier analysis and Cox’s proportional hazards model were used in survival analysis. MTT assay, wound healing assay, transwell assay and flow cytometry analysis were carried out to detect the impact of miR-622 on glioma cell proliferation, migration, invasion and apoptosis.Results: Our result indicated that miR-622 expression was greatly decreased in glioma tissues and cell lines and the downregulation of miR-622 was significantly associated with the advanced pathological grade and low Karnofsky performance score of glioma. In addition, Kaplan–Meier curves with log-rank analysis revealed a close correlation between downregulation of miR-622 expression and low overall survival rate
    • الموضوع:
    • Availability:
      Open access content. Open access content
      info:eu-repo/semantics/openAccess
    • Note:
      text/html
      English
    • Other Numbers:
      NZDMP oai:dovepress.com/48492
      1128858918
    • Contributing Source:
      DOVE MEDL PRESS LTD
      From OAIster®, provided by the OCLC Cooperative.
    • الرقم المعرف:
      edsoai.on1128858918
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