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Lab-on-Chip for testing myelotoxic effect of drugs and chemicals

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  • معلومة اضافية
    • Publisher Information:
      Springer Verlag 2015
    • نبذة مختصرة :
      In the last 20 years, one of the main goals in the drug discovery field has been the development of reliable in vitro models. In particular, in 2006 the European Centre for the Validation of Alternative Methods has approved the colony-forming unit granulocytes–macrophages test, which is the first and currently unique test applied to evaluate the myelotoxicity of xenobiotics in vitro. The present work aimed at miniaturizing this in vitro assay by developing and validating a Lab-on-Chip platform consisting of a high number of bioreactor chambers with screening capabilities in a high-throughput regime.
    • الموضوع:
      CB-MNC; CFU-GM; Clonogenic test; Lab-on-Chip; Microfluidics; Settore SECS-S/01 - STATISTICA; Settore MED/01 - STATISTICA MEDICA; Settore MED/07 - MICROBIOLOGIA E MICROBIOLOGIA CLINICA; info:eu-repo/semantics/article
    • Availability:
      Open access content. Open access content
    • Note:
      English
    • Other Numbers:
      SYC oai:publicatt.unicatt.it:10807/109486
      10.1007/s10404-015-1622-0
      info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84942981778
      1105031909
    • Contributing Source:
      UNIV CATTOLICA DEL SACRO CUORE
      From OAIster®, provided by the OCLC Cooperative.
    • الرقم المعرف:
      edsoai.on1105031909
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