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Simple Efficient Routes for the Preparation of Pyrazoleamines and Pyrazolopyrimidines: Regioselectivity of Pyrazoleamines Reactions with Bidentate Reagents

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اقرأ أكثر حفظ في قائمتي
  • المؤلفون: Moustafa Sherief Moustafa; Saleh Mohammed Al-Mousawi; Mohamed Hilmy Elnagdi
  • المصدر:
    Croatica Chemica Acta; ISSN 0011-1643 (Print); ISSN 1334-417X (Online); Volume 89; Issue 1
  • نوع التسجيلة:
    Electronic Resource
  • الدخول الالكتروني :
    https://hrcak.srce.hr/158793
    https://hrcak.srce.hr/file/234199
    info:eu-repo/semantics/altIdentifier/doi/10.5562/cca2738
  • معلومة اضافية
    • Publisher Information:
      Croatian Chemical Society 2016
    • نبذة مختصرة :
      Simple and efficient routes for the preparation of 2-amino-5-phenyl-4,5-dihydrofuran-3-carbonitrile (12), 2-oxo-5-phenyl-tetrahydrofuran-3-carbonitrile (13) and the 3,5-diaminopyrazole derivative 2h were developed. The results of the reactivity profiles of 12 and 2h are reported and the previously investigated reaction of pyrazole-3,5-diamine (2b) with acrylonitrile to yield compound (31), a N-1 acylation product, is currently justified by using X-ray crystallographic analysis. Taken together, the observation of alkenes and alkynes substitution when reacting with 3,5-diaminopyrazole derivative 2h is explained by the terminal electron withdrawing group. This pattern of substitution is attributed to involvement of sterically unhindered electrophiles primarily at the N-1 position. This work is licensed under a Creative Commons Attribution 4.0 International License.
    • الموضوع:
      diamino pyrazoles; reduction; Michael addition; pyrazolopyrimidines; cyclic enamines; text; info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion
    • Availability:
      Open access content. Open access content
      info:eu-repo/semantics/openAccess
      Croatica Chemica Acta is at the highest possible level of Open Access, meaning that all content is immediately and freely available to anyone, anywhere, to be downloaded, printed, distributed, read, reused, self archived, and re-mixed (including commercially) without restriction, as long as the author and the original source are properly at-tributed according to the Creative Commons Attribution 4.0 International License (CC BY). The author(s) hold the copyright and retain publishing rights without restrictions. CC BY (Creative Commons Attribution) is the most accommodating of public copyright licenses as defined by Creative Commons, a nonprofit organization that provides legal tools for sharing and use of creative works and research. The CC BY license is recommended for maximum dissemination and use of licensed materials. All content published in Croatica Chemica Acta is available under CC BY, meaning anyone is free to use and reuse the content provided the original source and authors are credited. The copyright is held and retained. The author(s) hold the copyright without restrictions. CC BY is the appropriate license for publicly funded research; it maximizes the potential for both economic and scholarly impact, protects the rights of authors and strengthens the long-standing tradition of appropriate attribution and credit for scholarship.
    • Note:
      application/pdf
      English
    • Other Numbers:
      HRCAK oai:hrcak.srce.hr:158793
      1077707307
    • Contributing Source:
      HRCAK PORTAL ZNANSTVENIH CASOPISA REPUB
      From OAIster®, provided by the OCLC Cooperative.
    • الرقم المعرف:
      edsoai.on1077707307
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