Kinon-metidi (I. dio): Reaktivni međuprodukti u kemiji fenola i njihova primjena u organskoj sintezi

Quinone Methides (Part I): Reactive Intermediates in the Chemistry of Phenols and Their Application in Organic Synthesis

Croatian Society of Chemical Engineers 2017

Kinon-metidi (QM, naziv po IUPAC-u: kinometani) su reaktivni međuprodukti koji zauzimaju vrlo značajno mjesto u organskoj kemiji. Njihova primjena u organskoj sintezi je veoma velika, što je dovelo do razvoja velikog broja metoda za njihovo generiranje. Korisni su i u stereoselektivnim reakcijama, čime im je otvoren put za primjenu u totalnoj sintezi, nerijetko struktura koje su već pokazale značajnu biološku aktivnost. Ovim pregledom dan je uvid u metode sintetskog (termičkog) generiranja QM-a te njihovu primjenu u organskoj sintezi, s osvrtom na biološka svojstva samih QM-a ili produkata koji se iz njih dobivaju u sintezi. Ovo djelo je dano na korištenje pod licencom Creative Commons Imenovanje 4.0 međunarodna.
Quinone methides (QMs, IUPAC name: quinomethanes) are reactive intermediates which are very important in organic chemistry. Their applications in organic synthesis are widely recognized, which has led to the development of a large number of methods for their generation. They are useful in stereoselective reactions, which open them the way for applications in total synthesis, often for structures that have already shown significant biological activity. This review gives an insight into the methods of synthetic (thermal) generation of QMs and their applications in organic synthesis, with an emphasis on the biological activity of QMs or the products obtained from them in the synthesis. This work is licensed under a Creative Commons Attribution 4.0 International License.

kinon-metidi; derivati fenola; termičko generiranje kinon-metida; kinon-metidi u organskoj sintezi; antiproliferativna aktivnost; quinone methides; phenol derivatives; thermal generation of quinone methides; quinone methides in organic synthesis; antiproliferative activity; text; info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion

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