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Modular bioink for 3D printing of biocompatible hydrogels: sol-gel polymerization of hybrid peptides and polymers

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  • معلومة اضافية
    • Publisher Information:
      Royal Society of Chemistry 2017-02-21
    • نبذة مختصرة :
      An unprecedented generic system allowing the 3D printing of peptide-functionalized hydrogels by soft sol–gel inorganic polymerization is presented. Hybrid silylated inorganic/bioorganic blocks are mixed in biological buffer in an appropriate ratio, to yield a multicomponent bioink that can be printed as a hydrogel without using any photochemical or organic reagent. Hydrolysis and condensation of the silylated precursors occur during the printing process and result in a covalent network in which molecules are linked through siloxane bonds. The viscosity of the colloidal solution used as bioink was monitored in order to set up the optimal conditions for extrusion printing. Grid-patterned hydrogel scaffolds containing a hybrid integrin ligand were printed using a pressure-driven rapid prototyping machine. Finally, they were seeded with mesenchymal stem cells, demonstrating their suitability for cell culture. The versatility of the sol–gel process and its biocompatibility makes this approach highly promising for the preparation of tailor-made cell-laden scaffolds.
      Postprint (published version)
    • الموضوع:
      Àrees temàtiques de la UPC::Enginyeria dels materials; Àrees temàtiques de la UPC::Enginyeria biomèdica; Biocompatible Materials; Polymers; Hydrogels--chemistry; Polímers; Materials biocompatibles; Article
    • Availability:
      Open access content. Open access content
      Attribution 3.0 Spain
      http://creativecommons.org/licenses/by/3.0/es
      Open Access
    • Note:
      5 p.
      application/pdf
      English
    • Other Numbers:
      HGF oai:upcommons.upc.edu:2117/104132
      Echalier, C., Levato, R., Mateos, M., Castaño, O., Dejean, S., Garric, X., Pinese, C., Noël, D., Engel, E., Martinez, J., Mehdi, A., Subra, G. Modular bioink for 3D printing of biocompatible hydrogels: sol-gel polymerization of hybrid peptides and polymers. "Journal of materials chemistry B", 21 Febrer 2017, vol. 7, p. 12231-12235.
      2050-750X
      10.1039/c6ra28540f
      987888807
    • Contributing Source:
      UNIV POLITECNICA DE CATALUNYA
      From OAIster®, provided by the OCLC Cooperative.
    • الرقم المعرف:
      edsoai.ocn987888807
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