Physiological and therapeutic glycosidic adaptation of host and graft in ABO(H)-incompatible transplantation, a hypothesis.

Figshare 2016 Created: 2016-06-14 Updated: 2016-06-14

In contrast to non-nucleated ABO(H)-incompatible red cells, which when transfused to a blood group O(H) recipient undergo destruction within minutes, such hyperacute, humoral rejection occurs relatively rare in transplantations of highly nucleated, metabolically active solid organs, and it is extremely rare in liver transplantations (Adams 1991; Della-Guardia et al. 2008). Moreover, a case of transient, selective disappearance of preexisting donor-specific HLA-antibodies after an incompatible liver transplantation, without any rejection episodes, has been reported by Bastiani (2006), and according to Taner et al. (2014), such transient decrease of donor-specific HLA-antibodies is not uncommon after liver transplantation. In addition, a transient exponential fall in both anti-A/B reactive IgM and IgG titers were also observed after ABO(H) incompatible bone marrow transplantation (Rowley et al. 2000; Lee et al. 2003).These phenomena most likely reflect a complex mechanism, in which an adsorption of host immunoglobulins on graft epitopes is completed by graft-phenotype-specific glycosylation of these immunoglobulins, and which suggests its targeted use in a hypothetical therapeutic principle.

60101 Analytical Biochemistry; Biological Techniques; Biotechnology; Developmental Biology; 60403 Developmental Genetics (incl. Sex Determination); 60107 Enzymes; Evolutionary Biology; Genetics; Immunology; Dataset

10.6084.M9.FIGSHARE.3394639.V115

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