Transforming growth factor beta-1 and interleukin-17 gene transcription in peripheral blood mononuclear cells and the human response to infection.

2010-06

The occurrence of severe sepsis may be associated with deficient pro-inflammatory cytokine production. Transforming growth factor beta-1 (TGFbeta-1) predominantly inhibits inflammation and may simultaneously promote IL-17 production. Interleukin-17 (IL-17) is a recently described pro-inflammatory cytokine, which may be important in auto-immunity and infection. We investigated the hypothesis that the onset of sepsis is related to differential TGFbeta-1 and IL-17 gene expression.
Journal Article
Research Support, Non-U.S. Gov't
SCOPUS: ar.j
info:eu-repo/semantics/published

Sciences bio-médicales et agricoles; Adrenal Cortex Hormones -- therapeutic use; Aged; Aged, 80 and over; Bacteremia -- genetics -- immunology; Case-Control Studies; Demography; Enzyme-Linked Immunosorbent Assay; Female; Gene Dosage -- genetics; Gene Expression Regulation; Humans; Interleukin-17 -- blood -- genetics; Leukocytes, Mononuclear -- metabolism; Male; RNA, Messenger -- genetics -- metabolism; Sepsis -- drug therapy -- genetics; Transcription, Genetic; Transforming Growth Factor beta1 -- blood -- genetics; Cytokine; Infection; Polymerase chain reaction; Sepsis; info:eu-repo/semantics/article; info:ulb-repo/semantics/articlePeerReview; info:ulb-repo/semantics/openurl/article

1 full-text file(s): application/pdf
English

EQY oai:dipot.ulb.ac.be:2013/128897
uri/info:doi/10.1016/j.cyto.2010.01.003
uri/info:pii/S1043-4666(10)00006-2
uri/info:pmid/20207161
uri/info:scp/77952544328
812604656

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