Ceftazidime- and imipenem-induced endotoxin release during treatment of gram-negative infections.

2001-11

To determine whether ceftazidime and imipenem, which target two different penicillin-binding proteins, result in different amounts of endotoxin and cytokine release in patients with gram-negative infection, plasma endotoxin, interleukin-6, and tumor necrosis factor alpha were measured during the first 24 h of antibiotic therapy in 27 patients with gram-negative infection who had been randomized to receive either ceftazidime 2 g t.i.d. (n=12) or imipenem/cilastatin 1 g t.i.d. (n=15). The source of infection was the digestive tract (n=13), the urinary tract (n=5), the respiratory tract (n=2), soft tissue (n=2), i.v. line (n=2), or other (n=3). After the first antibiotic injection, a significant increase in the median concentration of plasma interleukin-6 and plasma tumor necrosis factor alpha was noted, without significant differences related to the antibiotic administered. Antibiotic-induced endotoxemia was detectable in nine patients (including 7 with bacteremia). In conclusion, ceftazidime and imipenem had similar effects on endotoxin and cytokine release during the treatment of gram-negative infections.
Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
info:eu-repo/semantics/published

Sciences bio-médicales et agricoles; Bacteremia -- blood; Bacteremia -- drug therapy; Ceftazidime -- administration & dosage; Drug Administration Schedule; Endotoxins -- blood; Female; Gram-Negative Bacterial Infections -- blood; Gram-Negative Bacterial Infections -- drug therapy; Humans; Imipenem -- administration & dosage; Injections, Intravenous; Interleukin-6 -- blood; Male; Probability; Reference Values; Sensitivity and Specificity; Statistics, Nonparametric; Tumor Necrosis Factor-alpha -- analysis; info:eu-repo/semantics/article; info:ulb-repo/semantics/articlePeerReview; info:ulb-repo/semantics/openurl/article

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English

EQY oai:dipot.ulb.ac.be:2013/53258
uri/info:doi/10.1007/s100960100609
uri/info:pmid/11783697
uri/info:scp/0035663083
778634503

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