Genetic diversity of Group A Streptococcus M protein: implications for typing and vaccine development

2008-10

Group A Streptococci (GAS) are classified into 180 emm-types based on the sequence of the amino-terminal hyper-variable region of the M surface protein. The genetic relatedness of the whole surface-exposed part of M was investigated in well-characterized Belgian and Brazilian GAS isolates which belong to different epidemiological and clinical landscapes. Despite a small number of different emm-types and an apparent low diversity in the Belgian isolates (as revealed by the emm-typing method), our data showed that the overall genetic diversity of the M proteins was higher than expected. On the contrary, the M proteins from the Brazilian isolates were genetically highly related. Since M is a multi-functional protein, an analysis of the whole surface-exposed sequence that takes into account the different functional domains may provide tools for typing as well as for analyzing the molecular mechanisms of M virulence or defining vaccine strategies.
Journal Article
Research Support, Non-U.S. Gov't
SCOPUS: ar.j
info:eu-repo/semantics/published

Sciences bio-médicales et agricoles; Antigens, Bacterial -- genetics; Antigens, Bacterial -- immunology; Bacterial Outer Membrane Proteins -- genetics; Bacterial Outer Membrane Proteins -- immunology; Belgium -- epidemiology; Brazil -- epidemiology; Carrier Proteins -- genetics; Carrier Proteins -- immunology; Genes, Bacterial -- genetics; Genes, Bacterial -- immunology; Genetic Variation; Humans; Molecular Epidemiology; Phylogeny; Plasminogen -- metabolism; Repetitive Sequences, Nucleic Acid; Reverse Transcriptase Polymerase Chain Reaction; Streptococcal Infections -- epidemiology; Streptococcal Infections -- immunology; Streptococcal Infections -- microbiology; Streptococcal Vaccines -- genetics; Streptococcal Vaccines -- immunology; Streptococcus pyogenes -- genetics; Streptococcus pyogenes -- immunology; Group A Streptococcus; M protein; Vaccine; info:eu-repo/semantics/article; info:ulb-repo/semantics/articlePeerReview; info:ulb-repo/semantics/openurl/article

1 full-text file(s): application/pdf
English

EQY oai:dipot.ulb.ac.be:2013/51689
uri/info:doi/10.1016/j.vaccine.2008.08.037
uri/info:pii/S0264-410X(08)01131-6
uri/info:pmid/18789365
uri/info:scp/53449099372
764594979

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