Expression pattern of the orphan receptor LGR4/GPR48 gene in the mouse.

2005-07

Leucine-rich G-protein-coupled Receptors (LGR) constitute a subfamily of receptors related to glycoprotein hormone receptors. Amongst them, LGR4, LGR5 and LGR6 form a cluster for which natural agonists are still unknown. By an extensive gene trapping approach, Leighton et al. (2001) obtained a mouse line in which the LGR4 gene is disrupted by a trap vector carrying two biological markers, beta-geo (a fusion between bacterial beta-galactosidase and neomycin phosphotransferase) and a placental alkaline phosphatase (PLAP). Due to perinatal lethality, characterization of adult mice homozygous for this insertion has been impaired. In the present study we have investigated LacZ and PLAP activity patterns in heterozygous mice as a marker for LGR4 natural expression at both macroscopic and histological levels. We present a detailed atlas of LGR4 expression, which displays very wide expression with particularly strong activity in cartilages, kidneys, reproductive tracts and nervous system cells.
Journal Article
Research Support, Non-U.S. Gov't
info:eu-repo/semantics/published

Sciences bio-médicales et agricoles; Animals; Heterozygote; Mice; Phenotype; Receptors, G-Protein-Coupled -- genetics; Receptors, G-Protein-Coupled -- metabolism; Recombinant Proteins -- genetics; Recombinant Proteins -- metabolism; Tissue Distribution -- genetics; beta-Galactosidase -- genetics; GPCR; Leucine-rich repeats; LGR; Orphan receptor; info:eu-repo/semantics/article; info:ulb-repo/semantics/articlePeerReview; info:ulb-repo/semantics/openurl/article

Open access content. Open access content
1 full-text file(s): info:eu-repo/semantics/restrictedAccess

1 full-text file(s): application/pdf
English

EQY oai:dipot.ulb.ac.be:2013/52396
uri/info:doi/10.1007/s00418-005-0002-3
uri/info:pmid/16028069
uri/info:scp/24344490822
764587740

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