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Rosuvastatin Counteracts Vessel Arterialisation and Sinusoid Capillarisation, Reduces Tumour Growth, and Prolongs Survival in Murine Hepatocellular Carcinoma

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  • معلومة اضافية
    • بيانات النشر:
      Hindawi Limited, 2010.
    • الموضوع:
      2010
    • Collection:
      LCC:Diseases of the digestive system. Gastroenterology
    • نبذة مختصرة :
      Background and Aims. An arterial blood supply and phenotypic changes of the sinusoids characterise the liver vasculature in human hepatocellular carcinoma (HCC). We investigated the effects of rosuvastatin on liver vessel anomalies, tumour growth and survival in HCC. Methods. We treated transgenic mice developing HCC, characterized by vessel anomalies similar to those of human HCC, with rosuvastatin. Results. In the rosuvastatin group, the survival time was longer (P
    • File Description:
      electronic resource
    • ISSN:
      1687-6121
      1687-630X
    • Relation:
      https://doaj.org/toc/1687-6121; https://doaj.org/toc/1687-630X
    • الرقم المعرف:
      10.1155/2010/640797
    • الرقم المعرف:
      edsdoj.ff483bf9daf4c1cb24376d69f98916d