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Cancer cell-expressed BTNL2 facilitates tumour immune escape via engagement with IL-17A-producing γδ T cells

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اقرأ أكثر
  • معلومة اضافية
    • بيانات النشر:
      Nature Portfolio, 2022.
    • الموضوع:
      2022
    • Collection:
      LCC:Science
    • نبذة مختصرة :
      Cancer cells producing ligands for the immune checkpoint molecules PD-1 and CTLA-4 is an important mechanism of tumour immune resistance. Here authors show that BTNL2 expression on cancer cells generates a dysfunctional tumour immune microenvironment via promoting IL-17A-producing γδ T cells.
    • File Description:
      electronic resource
    • ISSN:
      2041-1723
    • Relation:
      https://doaj.org/toc/2041-1723
    • الرقم المعرف:
      10.1038/s41467-021-27936-8
    • الرقم المعرف:
      edsdoj.bc2c48f5c4eb46b6b81e3b0918f911d1