Effect of Selenium Nitrite Feeding for 28 Days on Food Intake and Growth of Rats

This experiment was aimed at verifying the 28 day oral toxicity test (GB 15193.22—2014) in accordance with the national food safety standard [11]. Rats were fed with a high amount in selenium nitrite for 28 consecutive days to observe its effect on food intake and growth of rats, and at the same time provide a basis for predicting the safety of selenium preparations consumed by the population and long-term consumption. The detection indicators included general condition, body weight, food intake, food utilization rate, and pathological examination. During the entire observation period, the animals in each dose group were generally in good condition, and no clinical symptoms related to the test substance were seen., showed a dose-dependent inhibition on the growth of body weight and food intake of male animals, especially the growth of animals in the high-dose group was significantly inhibited, and its body weight was significantly lower than that of the control group (P